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Structurally Aligned Multifunctional Neural Probe (SAMP) Using Forest-Drawn CNT Sheet onto Thermally Drawn Polymer
Woojin Jeon1, Jae Myeong Lee2,3, Yeji Kim1
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
Advanced Materials (Deerfield Beach, Fla.)
|March 29, 2024
Summary
A novel neural probe using carbon nanotube sheets offers superior performance for long-term brain recordings and interventions. This advanced carbon-based implant demonstrates over a year of in vivo functionality, advancing neuroscience research.
Area of Science:
- Neuroscience
- Materials Science
- Biomedical Engineering
Background:
- Neural probe engineering faces challenges in size, stiffness, complexity, and manufacturing for sustained in vivo use.
- Nanomaterial integration aims to enhance neural probe performance and biocompatibility for long-term implantation.
- Existing neural interfaces often struggle with long-term stability and multifunctionality.
Purpose of the Study:
- To develop a novel neural interface with improved electrical, mechanical, and electrochemical properties for long-term neuroscience applications.
- To address the limitations of current neural probes through advanced material integration and fabrication.
- To create a versatile and reliable platform for in vivo neural recording, neurotransmitter detection, and circuit manipulation.
Main Methods:
- Fabrication of a neural interface using freestanding carbon nanotube (CNT) sheets drawn from CNT-forests.
- Integration of CNT sheets onto thermally drawn functional polymer fibers to achieve structural alignment.
- In vivo testing of the Structurally Aligned Multifunctional neural Probe (SAMP) for neural recording, neurotransmitter detection, and optogenetics.
Main Results:
- The developed SAMP exhibits exceptional electrical, mechanical, and electrochemical properties due to structural alignment.
- The neural probe demonstrated sustained in vivo functionality for over a year post-implantation.
- Successful neural recording, neurotransmitter detection, and optogenetic manipulation of brain/spinal cord circuits were achieved.
Conclusions:
- The proposed fabrication method using forest-drawn CNT sheets offers a versatile and straightforward approach for next-generation carbon-based implants.
- The SAMP's longevity and multifunctionality establish it as a promising platform for long-term neuroscience research and clinical applications.
- Structurally aligned CNT-based neural probes represent a significant advancement in neural interface technology.
