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Retinal Ischemic Perivascular Lesions Are Associated With Myocardial Infarction in Patients With Coronary Artery
Elodie Bousquet1, Ahmad Santina2, Adrian Au2
1Form the Retinal Disorders and Ophthalmic Genetics Division (E.B., A.S., A.A., S.S., N.A., S.V., R.E., Y.A.F., V.R., D.S.), Stein Eye Institute, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Ophthalmology (E.B.), University of Paris Cité, Lariboisière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Insights
Retinal ischemic perivascular lesions (RIPLs) detected by OCT are linked to myocardial infarction (MI) in coronary artery disease (CAD) patients. This finding suggests RIPLs may aid in managing CAD and predicting MI risk.
Area of Science:
- Ophthalmology
- Cardiology
- Medical Imaging
Background:
- Coronary artery disease (CAD) is a significant health concern.
- Myocardial infarction (MI) is a major complication of CAD.
- Identifying novel biomarkers for MI risk in CAD patients is crucial.
Purpose of the Study:
- To investigate the association between retinal ischemic perivascular lesions (RIPLs) and myocardial infarction (MI).
- To determine if RIPLs can serve as a predictor for MI in patients with CAD.
Main Methods:
- A retrospective cross-sectional study involving 317 patients with CAD.
- Macular spectral domain optical coherence tomography (SD-OCT) was used to detect RIPLs.
- Multivariate logistic regression analysis adjusted for clinical covariates.
Main Results:
- A higher prevalence of RIPLs was found in CAD patients with a history of MI (59.3%) compared to those without MI (35.7%).
- RIPLs were significantly associated with MI (Odds Ratio = 3, P < .001) after adjusting for risk factors.
Conclusions:
- The presence of RIPLs, identified via SD-OCT, is significantly associated with MI in patients with CAD.
- RIPL evaluation may offer clinical utility in the comprehensive management of CAD patients.
Purpose:
To evaluate the association of retinal ischemic perivascular lesions (RIPLs) with myocardial infarction (MI) among patients diagnosed with coronary artery diseases (CAD).
Design:
Retrospective cross-sectional study.
Methods:
Consecutive patients (317 patients) with CAD who underwent macular spectral domain optical coherence tomography (SD-OCT) were captured. Patients with CAD who developed MI were compared to those without MI. SD-OCT were reviewed by 2 independent and masked graders for the presence of RIPLs. Medical records were reviewed. Multivariate logistic regression analysis was used to evaluate the relationship between RIPLs and MI including the following covariates age, gender, smoking status, hypertension, diabetes, dyslipidemia and body mass index.
Results:
Of 317 patients with CAD for whom OCT scans were available to study, there were 54 (17%) with a history of MI. A higher prevalence of RIPLs was observed in the MI group compared to the non-MI group (59.3% vs 35.7%; P < .001). The presence of RIPLs was significantly associated with MI with an odds ratio of 3 (1.91-4.74; P < .001), after adjusting for age, gender, smoking status, hypertension, diabetes, dyslipidemia, and body mass index.
Conclusions:
The presence of RIPLs, detected with SD-OCT, is significantly associated with MI in patients with CAD. These findings underscore the potential clinical utility of incorporating RIPL evaluation in the medical management of CAD.
