Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated AI-Based Aortic Measurements From Attenuation Correction CT as an Adjunctive Cardiovascular Risk Biomarker: An International Multicenter Study.

Circulation. Cardiovascular imaging·2026
Same author

CT Attenuation Map-Derived Body Composition Is Associated with Cardiorespiratory Fitness in Multicenter External Validation.

medRxiv : the preprint server for health sciences·2026
Same author

Epicardial Fat Necrosis as a Rare Cause of Chest Pain: Peeling Back the Layers.

JACC. Case reports·2026
Same author

Feasibility of Quantitative Myocardial Perfusion with CZT SPECT and SPECT/CT: Current Limitations and Recommendations for Future Improvements.

Current cardiology reports·2026
Same author

Low burden transthyretin cardiac amyloidosis on cardiac magnetic resonance: comprehensive phenotyping and distinction from hypertrophic phenocopies.

European heart journal. Imaging methods and practice·2026
Same author

<sup>99m</sup>Tc-4BOH and single-photon emission computed tomography imaging for measurement of myocardial blood flow.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2026
Same journal

Long-term evaluation of a web-based quality control management system (QATrack+) in diagnostic radiology.

Journal of medical imaging and radiation sciences·2026
Same journal

Out-of-field surface dose readings during panoramic radiography: Comparison of standard and manufacturer low-exposure protocols in an anthropomorphic phantom.

Journal of medical imaging and radiation sciences·2026
Same journal

Role expansion of radiological technologists in intraoperative fluoroscopy in Japan: A simulation-based social network analysis of interprofessional collaborative structure.

Journal of medical imaging and radiation sciences·2026
Same journal

Prevalence of the use of protective equipment for ionizing radiation from fluoroscopy: A systematic literature review and meta-analysis.

Journal of medical imaging and radiation sciences·2026
Same journal

The complementary roles of oversight, education, and collaboration in the responsible integration of artificial intelligence in radiation medicine: White paper of (CADRA).

Journal of medical imaging and radiation sciences·2026
Same journal

Navigating professional boundaries: The day my instructor became my patient.

Journal of medical imaging and radiation sciences·2026
See all related articles

Related Experiment Video

Updated: Jun 29, 2025

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

6.8K

Myocardial blood flow quantification with SPECT.

R Glenn Wells1, Gary R Small1, Terrence D Ruddy1

  • 1Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Journal of Medical Imaging and Radiation Sciences
|March 29, 2024
PubMed
Summary
This summary is machine-generated.

Single-photon emission computed tomography myocardial blood flow (MBF) offers improved accuracy for diagnosing and predicting outcomes in coronary artery disease. This nuclear medicine technique provides valuable clinical information for patient assessment.

Keywords:
Cardiovascular diseaseMyocardial perfusion imagingRegional blood flowReviewSingle-photon emission-computed tomography

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.6K
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

13.7K

Related Experiment Videos

Last Updated: Jun 29, 2025

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

6.8K
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.6K
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
12:29

Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

Published on: May 30, 2011

13.7K

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Medical Imaging

Background:

  • Absolute myocardial blood flow (MBF) enhances diagnostic and prognostic accuracy compared to relative perfusion imaging.
  • Nuclear medicine utilizing cardiac-specific gamma cameras enables MBF measurement via SPECT.

Purpose of the Study:

  • To review evidence supporting SPECT for myocardial blood flow (MBF) measurement.
  • To evaluate SPECT MBF against invasive methods, PET, and assess its repeatability.

Main Methods:

  • Review of studies evaluating SPECT MBF in animal models and human comparisons.
  • Comparison with invasive angiographic measurements and Positron Emission Tomography (PET) MBF.
  • Assessment of SPECT MBF repeatability in single-site and multi-center trials.

Main Results:

  • SPECT MBF shows excellent correlation with microspheres, fractional flow reserve, and PET-derived MBF.
  • Inter-user variability is approximately 20%, and test-retest variability is around 30%.
  • SPECT MBF improves sensitivity and specificity for detecting multi-vessel disease and predicts adverse cardiac events.

Conclusions:

  • SPECT MBF is a promising nuclear medicine technique.
  • It provides clinically valuable information for assessing coronary artery disease.
  • Enhances diagnostic and prognostic capabilities in cardiology.