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CRISPR-based identification of N-terminal acetylation in synucleinopathies

Eun-Jin Bae1, Seung-Jae Lee2

  • 1Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, South Korea; Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, South Korea.

Trends in Neurosciences
|March 29, 2024
PubMed
Abstract

Keywords:
NatBParkinson’s diseaseproteasomeprotein aggregationα-synuclein

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Phase II Reactions: Acetylation Reactions01:24

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Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...