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Related Experiment Video

Updated: Jun 29, 2025

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials
08:53

Quantifying Three-Dimensional Cell Migration Within and Into Granular Hydrogel Biomaterials

Published on: March 7, 2025

567

Microinterfaces in biopolymer-based bicontinuous hydrogels guide rapid 3D cell migration.

Karen L Xu1,2,3,4, Nikolas Di Caprio1,2, Hooman Fallahi5

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Nature Communications
|March 30, 2024
PubMed

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Summary

Researchers developed novel bicontinuous hydrogels that mimic natural cell migration pathways. These biopolymer systems promote rapid 3D cell movement, crucial for tissue regeneration and development.

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Cell migration is essential for tissue development and regeneration.
  • Cells navigate extracellular environments by remodeling them or following existing pathways.
  • Current 3D hydrogel models often fail to replicate natural cell migration routes.

Purpose of the Study:

  • To develop a novel biopolymer-based bicontinuous hydrogel system.
  • To investigate its capacity to support and guide rapid 3D cell migration.
  • To explore its utility in recapitulating natural cell migration pathways.

Main Methods:

  • Fabrication of a bicontinuous hydrogel system using enzymatically crosslinked gelatin and hyaluronic acid.
  • Controlled solution immiscibility to create continuous subdomains and high interfacial surface area.

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Last Updated: Jun 29, 2025

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567
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  • Assessment of cell migration across various cell types and in physiologically relevant contexts (spheroids, ex vivo, in vivo).

    • Main Results:

    • The bicontinuous hydrogels enabled rapid 3D cell migration, outperforming homogeneous hydrogels.
    • Cell migration observed was mesenchymal in nature.
    • Migration was effectively regulated by the hydrogel's biochemical and biophysical signals.

    Conclusions:

    • Bicontinuous hydrogels provide a biomimetic platform for studying cell migration.
    • This system leverages local interfaces to guide rapid cell migration in 3D.
    • The findings offer a new design strategy for advanced tissue engineering and regenerative medicine applications.