Search research articles

Related Concept Videos

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Home
Identification Of Spatially-resolved Markers Of Malignant Transformation In Intraductal Papillary Mucinous Neoplasms.

Home
Identification Of Spatially-resolved Markers Of Malignant Transformation In Intraductal Papillary Mucinous Neoplasms.

Related Experiment Video

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms.

Antonio Agostini^1,2, Geny Piro^3,4, Frediano Inzani⁵

¹Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Nature Communications

|March 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

New molecular markers for Intraductal Papillary Mucinous Neoplasm (IPMN) improve risk stratification. This study identifies subtype-specific markers, aiding in better treatment decisions for IPMN patients.

More Related Videos

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells

Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells

Published on: April 25, 2014

Related Experiment Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells

Three Dimensional Cultures: A Tool To Study Normal Acinar Architecture vs. Malignant Transformation Of Breast Cells

Published on: April 25, 2014

Area of Science:

Oncology
Molecular Biology
Genomics

Background:

Current Intraductal Papillary Mucinous Neoplasm (IPMN) risk stratification lacks molecular precision, leading to suboptimal patient management.
The absence of specific molecular markers hinders accurate diagnosis and targeted therapy selection for IPMN.

Purpose of the Study:

To identify and validate subtype-specific molecular markers for Intraductal Papillary Mucinous Neoplasm (IPMN) using spatial transcriptomics.
To elucidate the role of specific gene expression patterns and transcriptional networks in IPMN progression and Pancreatic Ductal Adenocarcinoma (PDAC) development.

Main Methods:

Utilized two independent patient cohorts and two Spatial Transcriptomics (ST) technologies to analyze IPMN gene expression profiles.
Performed subtype-specific marker identification for low-grade dysplasia, borderline, and high-grade dysplasia Gastric IPMN.

Main Results:

Identified HOXB3 and ZNF117 as markers for Low-Grade Dysplasia IPMN.
Identified SPDEF and gastric neck cell markers for borderline IPMN.
Identified NKX6-2 and gastric isthmus cell markers for High-Grade-Dysplasia Gastric IPMN, noting TNFα and MYC activation in progression.

Conclusions:

Discovered novel subtype-specific molecular markers for IPMN, enhancing diagnostic accuracy.
Confirmed the role of NKX6-2 in Gastric IPMN progression and highlighted TNFα and MYC pathways in overall IPMN advancement.
This research advances the understanding of IPMN gene expression and its link to Pancreatic Ductal Adenocarcinoma (PDAC) progression.