Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Area of Science:

• Oncology
• Biochemistry
• Cancer Biomarkers

Background:

• Triple-negative breast cancer (TNBC) is an aggressive subtype lacking standard targeted therapies.
• Identifying prognostic biomarkers is critical for personalized treatment strategies in TNBC.
• Heat shock protein 90 alpha (HSP90a) is investigated for its role in TNBC.

Purpose of the Study:

• To evaluate the prognostic value of HSP90a in triple-negative breast cancer.
• To determine the association between HSP90a levels and clinical characteristics, progression-free survival (PFS), and overall survival (OS) in TNBC patients.

Main Methods:

• Retrospective analysis of 127 TNBC patients and 127 healthy controls.
• Measurement of serum HSP90a, CEA, CA199, and CA125 levels.
• Statistical analysis including univariate and multivariate methods to identify independent risk factors for PFS and OS.

Main Results:

• HSP90a is upregulated in TNBC and correlates with lymph node metastasis and TNM stage.
• Multivariate analysis identified distant metastasis, TNM stage, and HSP90a level as independent factors for PFS.
• BMI, tumor size, TNM stage, surgical history, and HSP90a level were independent factors influencing OS.

Conclusions:

• Elevated HSP90a expression is significantly associated with adverse clinical features in TNBC.
• High HSP90a levels suggest a poorer prognosis and increased risk of progression and mortality in TNBC patients.