Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-dose ifosfamide in advanced osteosarcoma.

C Marti, T Kroner, W Remagen

    Cancer Treatment Reports
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Vibrational Quantum-State-Controlled Reactivity in the O<sub>2</sub><sup>+</sup> + C<sub>3</sub>H<sub>4</sub> Reaction.

    The journal of physical chemistry letters·2026
    Same author

    Screening for chemicals with thyroid hormone-disrupting effects using zebrafish embryo.

    Reproductive toxicology (Elmsford, N.Y.)·2023
    Same author

    Association between treatment duration and mortality or relapse in adult patients with Staphylococcus aureus bacteraemia: a retrospective cohort study.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    Accuracy of comprehensive PCR analysis of nasopharyngeal and oropharyngeal swabs for CT-scan-confirmed pneumonia in elderly patients: a prospective cohort study.

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019
    Same author

    Prevention of potentially inappropriate medication in internal medicine patients: A prospective study using the electronic application PIM-Check.

    Journal of clinical pharmacy and therapeutics·2018
    Same author

    Sex Differences in the Prevalence and Modulators of Sleep-Disordered Breathing in Outpatients with Type 2 Diabetes.

    Journal of diabetes research·2018
    Same journal

    Rhabdomyolysis associated with high-dose cytarabine.

    Cancer treatment reports·1987
    Same journal

    Acute laryngeal edema after single-dose irradiation and doxorubicin.

    Cancer treatment reports·1987
    Same journal

    Timing may be a critical factor in drug therapy.

    Cancer treatment reports·1987
    Same journal

    Prednimustine in advanced malignant melanoma: a phase II study.

    Cancer treatment reports·1987
    Same journal

    Phase II evaluation of diaziquone in pancreatic carcinoma: a Southwest Oncology Group Study.

    Cancer treatment reports·1987
    Same journal

    Teniposide in metastatic renal and bladder cancer: a Southwest Oncology Group Study.

    Cancer treatment reports·1987
    See all related articles

    High-dose ifosfamide chemotherapy, combined with mesna, shows promise for recurrent osteosarcoma. This treatment demonstrated therapeutic responses in 33% of patients with manageable toxicity, offering a potential new option for advanced bone cancer.

    Area of Science:

    • Oncology
    • Pharmacology
    • Bone Cancer Research

    Background:

    • Recurrent osteosarcoma presents a significant challenge in pediatric and young adult oncology.
    • Limited effective treatment options exist for patients with advanced or relapsed osteosarcoma.
    • Ifosfamide is a chemotherapeutic agent with known activity but potential toxicity.

    Purpose of the Study:

    • To evaluate the efficacy and safety of high-dose ifosfamide in patients with recurrent osteosarcoma.
    • To assess the therapeutic response rate and duration of response.
    • To document the toxicity profile, particularly urotoxicity and central nervous system effects.

    Main Methods:

    • Prospective study involving 18 evaluable patients with measurable lung deposits from recurrent osteosarcoma.

    Related Experiment Videos

  • Treatment regimen: Ifosfamide (1.8 g/m2 daily for 5 days) repeated every 4 weeks.
  • Concurrent administration of mesna (2-mercaptoethane sulfonate) to mitigate urotoxicity.

    • Main Results:

    • A 33% therapeutic response rate was observed (2 complete, 4 partial responses).
    • Median duration of response was 5.5 months (range, 3-47+ months).
    • Common toxicities included myelosuppression, alopecia, nausea, and vomiting; severe urotoxicity and CNS toxicity were not observed.

    Conclusions:

    • High-dose ifosfamide, when administered with mesna, appears to be a safe and effective chemotherapy option for recurrent osteosarcoma.
    • The observed response rate and manageable toxicity profile support its use in this patient population.
    • Further investigation may be warranted to optimize its role in osteosarcoma treatment protocols.