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Updated: Jun 29, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Data- and theory-driven approaches for understanding paths of epithelial-mesenchymal transition
Tian Hong1, Jianhua Xing2,3,4
1Department of Biochemistry & Cellular and Molecular Biology, The University of Tennessee, Knoxville, Tennessee, USA.
Abstract:
Reversible transitions between epithelial and mesenchymal cell states are a crucial form of epithelial plasticity for development and disease progression. Recent experimental data and mechanistic models showed multiple intermediate epithelial-mesenchymal transition (EMT) states as well as trajectories of EMT underpinned by complex gene regulatory networks. In this review, we summarize recent progress in quantifying EMT and characterizing EMT paths with computational methods and quantitative experiments including omics-level measurements. We provide perspectives on how these studies can help relating fundamental cell biology to physiological and pathological outcomes of EMT.
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