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Related Concept Videos

Tension Response at Adherens Junctions01:26

Tension Response at Adherens Junctions

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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Related Experiment Video

Updated: Jun 29, 2025

Author Spotlight: Advancing Tendon Research by Developing Mouse Assembloids to Understand Cellular Mechanisms
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A mechanics-based model for a tendon-driven active needle navigating inside a multiple-layer tissue.

Blayton Padasdao1, Bardia Konh2

  • 1University of Hawaii at Manoa, Honolulu, HI, 96822, USA.

Journal of Robotic Surgery
|March 30, 2024
PubMed
Summary
This summary is machine-generated.

A new model accurately predicts the deflection of a tendon-driven active needle navigating through multi-layer soft tissues. This advancement enhances precision for minimally invasive procedures like brachytherapy and biopsy.

Keywords:
Active tendon-driven needleMechanics-based modelReal-time trackingRobotic controlUltrasound tracking

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Area of Science:

  • Medical Robotics and Devices
  • Biomedical Engineering
  • Surgical Navigation

Background:

  • Percutaneous procedures such as brachytherapy and biopsy demand flexible active needles for precise tissue navigation and accurate target placement.
  • Previous research introduced a tendon-driven active needle for tissue navigation, necessitating further development for complex tissue environments.

Purpose of the Study:

  • To develop and validate a novel predictive model for the deflection of a tendon-driven active needle.
  • To assess the model's accuracy in steering through multiple-layer soft tissues with varying mechanical properties.

Main Methods:

  • A multi-layer phantom tissue with localized stiffness variations was created and characterized using indentation tests.
  • A robotic system was employed to insert and actively bend the tendon-driven needle within the phantom tissue.
  • Ultrasound imaging was utilized for real-time needle tracking during insertion and bending experiments for model validation.

Main Results:

  • The developed model demonstrated high accuracy in predicting needle deflection within the multi-layer soft tissue phantom.
  • Comparison between simulation results from the proposed model and empirical data confirmed its predictive capabilities.
  • The model effectively captured needle behavior in heterogeneous tissue environments with differing stiffness.

Conclusions:

  • The validated model provides accurate predictions of tendon-driven active needle deflection in multi-layer soft tissues.
  • This predictive capability is crucial for enhancing the precision and success rates of image-guided minimally invasive procedures.
  • The developed model represents a significant step towards improved robotic needle steering in complex anatomical regions.