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The association between calreticulin and glucagon-like peptide-1 expressions with prognostic factors in high-grade gliomas

  • 0Department of Neurosurgery, Koç University Hospital, Istanbul, Turkey.
Journal of Cancer Research and Therapeutics +

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March 30, 2024

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March 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

High-grade gliomas exhibit elevated Calreticulin (CALR) and reduced Glucagon-like peptide-1 (GLP-1) levels compared to normal brain tissue. These molecular changes correlate with tumor grade and IDH-1 mutation status.

Area Of Science

  • Neuro-oncology
  • Molecular biology
  • Biochemistry

Background

  • High-grade gliomas (HGG) are aggressive brain tumors with limited therapeutic options.
  • Understanding the molecular landscape of HGG is crucial for developing targeted therapies.
  • Calreticulin (CALR) and Glucagon-like peptide-1 (GLP-1) are proteins with potential roles in cancer biology.

Purpose Of The Study

  • To investigate the expression levels of CALR and GLP-1 in HGG.
  • To determine the correlation between CALR and GLP-1 levels and HGG grade.
  • To explore the relationship between CALR/GLP-1 expression, Ki-67 index, and IDH-1 mutation status.

Main Methods

  • Analysis of tumor samples from 43 HGG patients (grades III and IV) and 27 control subjects.
  • Enzyme assays to quantify CALR and GLP-1 levels in tissue samples.
  • Statistical analysis to correlate molecular markers with clinical and pathological features.

Main Results

  • HGG tissues showed significantly higher CALR and lower GLP-1 levels than controls (P=0.001).
  • Grade IV gliomas had higher CALR and lower GLP-1 than grade III gliomas (P=0.001).
  • CALR expression was higher in IDH-1 negative gliomas, while GLP-1 expression was higher in IDH-1 positive gliomas (P=0.01).
  • A positive correlation was found between Ki-67 and CALR, and a negative correlation between Ki-67 and GLP-1 in grade IV gliomas (P=0.001).

Conclusions

  • Elevated CALR and reduced GLP-1 expression are characteristic of HGG.
  • These molecular markers may serve as potential biomarkers for HGG progression and IDH-1 mutation status.