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  11. Epithelial Ovarian Cancer In Younger Age Versus Older Age Groups: Survival And Clinicopathological Features.

Epithelial ovarian cancer in younger age versus older age groups: Survival and clinicopathological features.

Walaiporn Kongkamsuan1, Sathana Boonyapipat

  • 1Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla.

Journal of Cancer Research and Therapeutics
|March 30, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Younger epithelial ovarian cancer (EOC) patients have better progression-free survival (PFS) but similar disease-specific survival (DSS) compared to older patients. Younger age is a poor prognostic factor early on, but becomes favorable after three years.

Area of Science:

  • Gynecologic Oncology
  • Clinical Cancer Research
  • Epidemiology

Background:

  • Epithelial ovarian cancer (EOC) survival and characteristics can vary significantly with patient age.
  • Understanding age-related differences is crucial for optimizing treatment and prognostic assessments in EOC.

Purpose of the Study:

  • To compare survival outcomes and clinicopathological features of EOC in patients aged ≤40 years versus >40 years.
  • To determine the impact of younger age on EOC prognosis over time.

Main Methods:

  • Matched cohort study comparing 763 EOC patients (≤40 years vs. >40 years) at a 1:4 ratio.
  • Analysis of disease-specific survival (DSS), progression-free survival (PFS), and clinicopathological features.
  • Statistical comparison of outcomes between the two age groups.

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Main Results:

  • No significant difference in median DSS between younger and older EOC patients (120 vs. 84.7 months).
  • Younger patients demonstrated significantly better median PFS (not reached vs. 41 months).
  • Younger patients had higher rates of early-stage disease, mucinous subtype, and lower CA-125 levels.

Conclusions:

  • Younger EOC patients exhibit more favorable prognostic factors and improved PFS, but not DSS, compared to older counterparts.
  • Younger age is an unfavorable prognostic factor within 3 years post-diagnosis, transitioning to a favorable factor thereafter.