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Dioon rzedowskii: An antioxidant, antibacterial and anticancer plant extract with multi-faceted effects on cell

Walaa A Negm1, Engy Elekhnawy2, Sebaey Mahgoub3

  • 1Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.

International Immunopharmacology
|March 30, 2024
PubMed

Insights

Dioon rzedowskii extract demonstrates significant anticancer and antibacterial properties. This natural compound effectively inhibited cancer cell growth, reduced tumor volume in mice, and showed activity against K. pneumoniae.

Area of Science:

  • Phytochemistry
  • Pharmacology
  • Cancer Biology

Background:

  • Natural products are increasingly explored for therapeutic potential.
  • Dioon rzedowskii extract's biological activities, including antioxidant, anticancer, and antibacterial effects, were previously uninvestigated.
  • Understanding the molecular mechanisms of natural compounds is crucial for drug development.

Purpose of the Study:

  • To investigate the antioxidant, anticancer, and antibacterial properties of Dioon rzedowskii extract.
  • To evaluate the extract's efficacy against liver (HepG2) and breast (MCF-7) cancer cell lines.
  • To assess the extract's impact on a solid Ehrlich carcinoma (SEC) mouse model and elucidate underlying molecular pathways.

Main Methods:

  • In vitro assays for antioxidant, anticancer, and antibacterial activities.
  • In vivo study using a solid Ehrlich carcinoma (SEC) mouse model with varying extract doses (100 mg/kg and 200 mg/kg).
  • Analysis of molecular mechanisms including apoptosis induction, cell cycle regulation (p53, Bax, cyclin D1), and MAPK signaling pathway modulation.

Main Results:

  • Dioon rzedowskii extract inhibited proliferation and induced apoptosis in MCF-7 and HepG2 cancer cells in a dose-dependent manner.
  • In vivo, the extract reduced tumor volume, improved liver, heart, and kidney functions, and alleviated oxidative stress in tumor tissues.
  • Anticancer effects were linked to p53 and Bax overexpression, cyclin D1 downregulation, and decreased phosphorylated MAPK, alongside antibacterial activity against K. pneumoniae.

Conclusions:

  • Dioon rzedowskii extract exhibits significant anticancer and antibacterial properties, suggesting its potential as an adjunctive cancer therapy.
  • The extract's mechanism involves modulating key cancer-related genes and signaling pathways.
  • Further research is warranted to explore the combined efficacy and therapeutic applications of Dioon rzedowskii in cancer management.
Keywords:
Antibacterial activityDioon rzedowskiiMAPK pathwaySolid Ehrlich carcinomaToxicity profile

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