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Updated: Jun 29, 2025
09:06
Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
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PPARs in atherosclerosis: The spatial and temporal features from mechanism to druggable targets
Yi Zheng1, Mingyan Shao2, Yanfei Zheng2
1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
Journal of Advanced Research
|March 30, 2024
Summary
Peroxisome proliferator-activated receptors (PPARs) offer precise anti-atherosclerosis therapy by targeting specific cells and disease stages. PPAR modulators and agonists show promise for future cardiovascular drug development.
Area of Science:
- Cardiovascular Research
- Pharmacology
- Molecular Biology
Background:
- Atherosclerosis is a complex, chronic disease linked to global cardiovascular mortality.
- Lipid disorder and inflammation are key drivers of atherosclerosis pathogenesis.
- Peroxisome proliferator-activated receptors (PPARs) are critical targets for anti-atherosclerosis strategies.
Purpose of the Study:
- To systematically review PPAR roles in atherosclerosis across pathological stages and cell types.
- To explore pharmacological and clinical studies of PPARs for precise therapeutic strategies.
- To provide insights into novel drug development targeting PPARs for atherosclerosis.
Main Methods:
- Literature review of spatial and temporal characteristics of atherosclerosis.
- Analysis of PPAR functions in endothelial cells, macrophages, and vascular smooth muscle cells.
- Evaluation of selective PPAR modulators and PPAR-pan agonists.
Main Results:
- PPARs modulate endothelial dysfunction, macrophage lipid metabolism, and VSMC proliferation.
- Selective PPAR modulators offer tissue and cell-specific effects.
- PPAR-pan agonists show potential for balancing efficacy and reducing side effects.
Conclusions:
- Stage- and cell type-dependent precision therapy targeting PPARs is crucial for atherosclerosis.
- Understanding cell-specific PPAR mechanisms supports tailored drug development.
- PPAR-based therapies, including modulators and agonists, offer a promising avenue for cardiovascular disease treatment.
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