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  11. Elucidating The Role Of Mical1 In Pan-cancer Using Integrated Bioinformatics And Experimental Approaches

Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches

Canxuan Li1, Yunfei Xiao2,3,4, Jianqiu Kong2,3,4

  • 1Department of Urology, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, Guangdong, P. R. China.

Cell Adhesion & Migration
|March 31, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Molecule interacting with CasL 1 (MICAL1) is a key protein in cancer. This study reveals MICAL1

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Molecule interacting with CasL 1 (MICAL1) is a crucial protein regulating cell motility, axon guidance, cytoskeletal dynamics, and gene transcription.
  • MICAL1's role in cancer pathogenesis remains incompletely understood across diverse tumor types.

Purpose of the Study:

  • To comprehensively analyze the expression, diagnostic, and prognostic value of MICAL1 in a pan-cancer context.
  • To investigate the associations between MICAL1 and tumor characteristics, immune infiltration, and drug sensitivity.
  • To explore the functional role of MICAL1 in cancer, specifically in renal carcinoma.

Main Methods:

  • Bioinformatic analysis of MICAL1 expression across 33 cancer types using public datasets.
  • Assessment of MICAL1's correlation with clinical parameters, immune markers, and drug sensitivity.
Keywords:
BioinformaticsMICAL1immune pathwayspan-cancer

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  • Functional experiments were conducted on renal carcinoma cells to elucidate MICAL1's cellular functions.

    • Main Results:

    • MICAL1 exhibited dysregulated expression across various cancer types, suggesting its involvement in tumorigenesis.
    • MICAL1 expression levels were significantly associated with tumor stage, immune cell infiltration, and patient prognosis.
    • Enrichment analyses indicated MICAL1's potential roles in metastasis, angiogenesis, metabolism, and immune response pathways.
    • Functional assays confirmed MICAL1's impact on the behavior of renal carcinoma cells.

    Conclusions:

    • MICAL1 is a potential diagnostic and prognostic biomarker in multiple cancer types.
    • MICAL1 may serve as a therapeutic target, particularly in cancers where its dysregulation is prominent.
    • Further research is warranted to fully elucidate MICAL1's complex role in cancer development and progression.
    tumor immune microenvironment