Prognostic analysis of sex and age in hepatocellular carcinoma: a SEER study
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View abstract on PubMed
Summary
This summary is machine-generated.Sex impacts hepatocellular carcinoma (HCC) survival, with younger males and females receiving chemotherapy showing better outcomes. Age, gender, and chemotherapy influence HCC prognosis for all patients.
Area Of Science
- Hepatobiliary Medicine
- Cancer Research
- Clinical Epidemiology
Background
- Hepatocellular carcinoma (HCC) is a significant global health concern.
- Understanding prognostic factors is crucial for effective HCC management.
- The influence of sex on HCC clinical features and survival requires further investigation.
Purpose Of The Study
- To investigate the impact of sex on clinical characteristics.
- To analyze sex-based differences in survival outcomes for hepatocellular carcinoma patients.
- To identify key prognostic factors influencing HCC survival.
Main Methods
- Analysis of HCC case data from the Surveillance, Epidemiology, and End Results (SEER) database (2010-2015).
- Kaplan-Meier curves for overall survival assessment.
- Univariate and multivariate Cox regression analyses to determine prognostic factors and hazard ratios.
Main Results
- A cohort of 3486 HCC patients (2682 males, 804 females) was analyzed.
- Males were more prevalent across all age groups; younger males (<60) had higher survival rates than older males (≥60).
- Chemotherapy improved survival in females but not in males; age, gender, and chemotherapy were key prognostic factors.
Conclusions
- Age, sex, and chemotherapy administration significantly influence hepatocellular carcinoma prognosis.
- These factors are critical for both male and female HCC patient outcomes.
- Tailored treatment strategies considering these variables may improve patient survival.
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