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Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
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An initial test of the contrast avoidance model in bipolar spectrum disorders
Hanjoo Kim1, Melvin G McInnis1, Sarah H Sperry2
1Heinz C. Prechter Bipolar Research Program, Department of Psychiatry, The University of Michigan, Michigan, USA.
Journal of Psychiatric Research
|March 31, 2024
Summary
Individuals with bipolar spectrum disorders (BSDs) show higher contrast avoidance traits, suggesting this psychological mechanism may contribute to the disorder. This study explored the link between the Contrast Avoidance Model and BSDs.
Area of Science:
- Psychology
- Psychiatry
- Emotional Regulation
Background:
- The Contrast Avoidance Model explains how individuals manage negative emotional shifts.
- Bipolar spectrum disorders (BSDs) involve significant mood fluctuations, potentially leading to heightened emotional contrasts.
- The relationship between contrast avoidance and BSDs remains empirically untested.
Purpose of the Study:
- To investigate group differences in contrast avoidance traits between individuals with BSDs, unipolar depression, and healthy controls.
- To explore the potential role of the Contrast Avoidance Model in understanding BSDs.
Main Methods:
- A large cohort study with 536 participants.
- Comparison of contrast avoidance questionnaire scores across three groups: BSDs, unipolar depression, and healthy controls.
- Analysis of specific factors within the Contrast Avoidance Questionnaire-General Emotion (CAQ-GE).
Main Results:
- Individuals with BSDs scored significantly higher on total contrast avoidance traits compared to unipolar depression and healthy controls.
- Higher scores were observed in factors like Discomfort with Negative Emotional Shifts and Avoidance of Negative Emotional Contrasts/Enhancement of Positive Emotional Contrasts.
- Bipolar II disorder subtype showed a stronger tendency to avoid negative emotional contrasts than Bipolar I disorder.
Conclusions:
- Contrast avoidance may represent a significant psychological mechanism implicated in bipolar spectrum disorders.
- These findings provide empirical support for the application of the Contrast Avoidance Model to BSDs.
- Further research into contrast avoidance could inform therapeutic strategies for mood disorders.

