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Enhancing the uptake of Core Outcome Sets (COS) requires strong partnerships with collaborators and addressing their needs. Patient involvement and awareness are key to improving COS impact in clinical research.

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Area of Science:

  • Health Research Methodology
  • Clinical Trial Design
  • Patient-Centered Outcomes

Background:

  • Core Outcome Sets (COS) are crucial for standardizing outcomes in research.
  • Previous studies show variable uptake rates for individual core outcomes.
  • Barriers to COS adoption include lack of validated instruments and insufficient stakeholder involvement.

Purpose of the Study:

  • To highlight the importance of enhancing Core Outcome Set (COS) uptake.
  • To emphasize building partnerships with collaborators and addressing their needs in COS development.
  • To explore strategies for improving the relevance and impact of COS in clinical research.

Main Methods:

  • A simulation session structured like a game show was used.
  • Eight collaborator groups discussed the importance of COS in their fields.
  • Analysis of identified barriers to COS uptake was conducted.

Main Results:

  • Disparities in uptake rates for individual core outcomes were observed.
  • Key barriers identified include lack of validated instrument recommendations, insufficient patient and collaborator involvement, and low awareness of COS.
  • Prioritizing patient and diverse collaborator inclusion in COS development is essential.

Conclusions:

  • COS development must prioritize patient and diverse collaborator inclusion.
  • Future research should explore broader COS implementation and influencing factors.
  • Extending COS development to recommend validated instruments and embracing patient leadership are vital for advancing COS impact.