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Updated: Jun 29, 2025

Author Spotlight: Assessing the Feasibility of Using Amplitude-Integrated EEG During Neonatal Transport

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Neonatal high frequency ventilation: Current trends and future directions.

Sherry E Courtney¹, Anton H van Kaam², J Jane Pillow³

¹Department of Pediatrics, Section of Neonatology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, One Children's Way, Little Rock, AR 72202 USA.

Seminars in Perinatology

|March 31, 2024

Summary

High frequency ventilation (HFV) offers advanced options like high frequency oscillatory ventilation (HFOV) and high frequency jet ventilation (HFJV) for neonates. Novel high frequency non-invasive ventilation (hfNIV) is under investigation, with efficacy and safety yet to be established.

Keywords:

High frequency non-invasive ventilation High frequency oscillatory ventilation Jet ventilation Neonatal ventilation

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Area of Science:

Neonatal respiratory support
Mechanical ventilation technologies

Background:

High frequency ventilation (HFV) has been utilized in neonates for over four decades.
While some early HFV devices are obsolete, high frequency oscillatory ventilation (HFOV) and high frequency jet ventilation (HFJV) remain in common clinical use.

Purpose of the Study:

To review current approaches to HFV therapies in neonates.
To emphasize the importance of understanding device-specific mechanisms and optimal disease applications.
To discuss the emerging application of high frequency non-invasive ventilation (hfNIV).

Main Methods:

Review of existing literature and clinical practices regarding HFV modalities.
Description of advanced features in contemporary HFOV systems.
Discussion of HFJV's utility in specific neonatal respiratory conditions.
Exploration of hfNIV as an investigational HFV approach.

Main Results:

Advanced HFOV models offer enhanced features like quieter operation, ease of use, tidal volume targeting, and integration with conventional ventilators.
HFJV demonstrates particular efficacy in managing air leaks and non-homogenous lung diseases.
hfNIV, while novel and applied with various devices, requires further investigation to establish its efficacy and safety profile.

Conclusions:

Understanding the operational principles and disease-specific benefits of HFOV and HFJV is crucial for optimizing neonatal respiratory care.
Further research is necessary to validate the clinical utility of hfNIV in the neonatal population.