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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Ageing-related Considerations For Medication Used In Supportive Care In Cancer

Ageing-related considerations for medication used in supportive care in cancer

Darren J Walsh1, Michelle O'Driscoll2, Laura J Sahm3

  • 1Pharmacy Department, University Hospital Waterford, Waterford, Ireland; Oncology Department, University Hospital Waterford, Waterford, Ireland; Pharmaceutical Care Research Group, School of Pharmacy, University College Cork, Cork, Ireland.

Journal of Geriatric Oncology
|March 31, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Comprehensive geriatric assessment (CGA) improves quality of life for cancer patients on systemic anti-cancer therapy (SACT). This review examines adverse drug events from supportive care medications in older adults, highlighting age-related changes and prescribing considerations.

Area of Science:

  • Geriatric Oncology
  • Clinical Pharmacology
  • Cancer Supportive Care

Background:

  • Comprehensive geriatric assessment (CGA) improves quality of life and reduces toxicity in patients undergoing systemic anti-cancer therapy (SACT).
  • Data on adverse drug events (ADEs) from supportive care medications in older adults receiving SACT are limited.
  • Older adults are often underrepresented in pharmacokinetic and pharmacodynamic studies, impacting medication safety.

Purpose of the Study:

  • To review age-related changes in pharmacokinetics and pharmacodynamics affecting supportive care medications.
  • To discuss prescribing considerations for supportive care medications in older adults with cancer.
  • To provide recommendations for commonly used supportive care medications in this population.

Main Methods:

Keywords:
AgeingFrailtyPharmacodynamicsPharmacokinetics

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  • Literature review of pharmacokinetic and pharmacodynamic changes related to aging.
  • Analysis of factors influencing medication prescribing in older cancer patients, including polypharmacy and drug-drug interactions.
  • Synthesis of recommendations for supportive care medication use.

    • Main Results:

    • Aging alters drug absorption, distribution, metabolism, and excretion, influencing medication efficacy and toxicity.
    • Polypharmacy, potentially inappropriate medications, and anticholinergic burden are significant concerns in older adults with cancer.
    • Specific recommendations for managing common supportive care medications in this demographic are provided.

    Conclusions:

    • Optimizing supportive care medication use in older adults with cancer requires careful consideration of age-related physiological changes.
    • Addressing polypharmacy and drug interactions is crucial for improving safety and quality of life.
    • Further research is needed to fully elucidate the impact of CGA on ADEs from supportive care medications.
    Polypharmacy