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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 29, 2025

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

Published on: March 6, 2012

Radiotherapy protocols for mouse cancer model.

Eneko Garate-Soraluze¹, Javier Marco-Sanz², Irantzu Serrano-Mendioroz¹

¹Program of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), Pamplona, Spain.

Methods in Cell Biology

|March 31, 2024

Summary

This summary is machine-generated.

This study introduces precise radiotherapy protocols for preclinical cancer research. These methods aim to improve the translation of mouse model findings to human cancer treatment outcomes.

Keywords:

Intracranial tumor Irradiation Orthotopic tumor Subcutaneous tumor

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Last Updated: Jun 29, 2025

Combination Radiotherapy in an Orthotopic Mouse Brain Tumor Model

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Published on: March 6, 2012

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Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

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Published on: December 16, 2022

Area of Science:

Oncology
Radiation Oncology
Preclinical Cancer Research

Background:

Radiotherapy is a key cancer treatment, with ~60% of patients receiving ionizing radiation.
Advancements focus on minimizing irradiation fields and increasing local doses.
A gap exists between preclinical findings and clinical outcomes in radiotherapy.

Purpose of the Study:

To present comprehensive radiotherapy protocols for preclinical studies.
To bridge the gap between experimental results and patient outcomes.
To improve the translatability of preclinical radiotherapy research.

Main Methods:

Utilized a small animal radiation research platform for precise X-ray delivery.
Developed protocols for orthotopic melanoma and glioblastoma tumor treatments.
Focused on localized irradiation to minimize side effects on healthy tissues.

Main Results:

Established detailed radiotherapy protocols mimicking clinical techniques.
Demonstrated a framework for preclinical studies with enhanced translatability.
Aimed to improve the correlation between mouse models and human patient outcomes.

Conclusions:

The presented protocols offer a valuable framework for preclinical radiotherapy research.
These methods can enhance the accuracy and relevance of findings from animal models.
Improved preclinical models are crucial for advancing cancer treatment strategies.