Elucidating the pathogenesis behind arteriovenous malformations of the central nervous system: a bibliometric...

Area of Science:

• Neuroscience
• Genetics
• Vascular Biology

Background:

• Arteriovenous malformations (AVMs) are complex vascular anomalies of the central nervous system (CNS).
• The precise pathophysiological mechanisms underlying AVM formation are not fully elucidated.
• Understanding AVM pathogenesis is crucial for developing effective therapeutic strategies.

Purpose of the Study:

• To conduct a bibliometric analysis of highly cited literature on AVM pathogenesis.
• To map the evolution of research trends and identify key areas of focus in AVM studies.
• To provide an overview of the historical development and current landscape of AVM research.

Main Methods:

• A comprehensive search of the Web of Science database was performed.
• The top 100 most-cited articles discussing AVM pathogenesis were selected.
• Bibliometric parameters including publication year, article type, author count, journal impact factor, and country of origin were analyzed.

Main Results:

• The analysis included 1863 articles, with the top 100 selected based on citation count.
• Research composition included 24% basic science, 46% clinical, and 30% review articles.
• The United States dominated contributions (approx. 70%), with VEGF and RAS/MAPK pathways identified as key areas of genetic investigation over time.

Conclusions:

• There is a discernible increase in research interest concerning AVM genomics and pathogenesis.
• While clinical aspects and risk factors are better understood, the fundamental genetic basis and pathophysiological mechanisms of AVMs require further exploration.
• Identifying key genes involved in AVM pathogenesis may unveil potential therapeutic targets for future interventions.