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Elucidating the pathogenesis behind arteriovenous malformations of the central nervous system: a bibliometric
Maria D Astudillo Potes1,2,3, Megan M J Bauman1,2, Ali Shoushtari2
1Mayo Clinic Alix School of Medicine, Rochester, Minnesota, USA.
Insights
Bibliometric analysis reveals evolving research on arteriovenous malformations (AVMs) pathogenesis. Despite progress in clinical aspects, the exact genetic basis and pathophysiological mechanisms of AVMs remain unclear, necessitating further gene investigation.
Area of Science:
- Neuroscience
- Genetics
- Vascular Biology
Background:
- Arteriovenous malformations (AVMs) are complex vascular anomalies of the central nervous system (CNS).
- The precise pathophysiological mechanisms underlying AVM formation are not fully elucidated.
- Understanding AVM pathogenesis is crucial for developing effective therapeutic strategies.
Purpose of the Study:
- To conduct a bibliometric analysis of highly cited literature on AVM pathogenesis.
- To map the evolution of research trends and identify key areas of focus in AVM studies.
- To provide an overview of the historical development and current landscape of AVM research.
Main Methods:
- A comprehensive search of the Web of Science database was performed.
- The top 100 most-cited articles discussing AVM pathogenesis were selected.
- Bibliometric parameters including publication year, article type, author count, journal impact factor, and country of origin were analyzed.
Main Results:
- The analysis included 1863 articles, with the top 100 selected based on citation count.
- Research composition included 24% basic science, 46% clinical, and 30% review articles.
- The United States dominated contributions (approx. 70%), with VEGF and RAS/MAPK pathways identified as key areas of genetic investigation over time.
Conclusions:
- There is a discernible increase in research interest concerning AVM genomics and pathogenesis.
- While clinical aspects and risk factors are better understood, the fundamental genetic basis and pathophysiological mechanisms of AVMs require further exploration.
- Identifying key genes involved in AVM pathogenesis may unveil potential therapeutic targets for future interventions.
Abstract:
Arteriovenous malformations (AVMs) are vascular malformations of the central nervous system (CNS) with potential for significant consequences. The exact pathophysiologic mechanism of AVM formation is not fully understood. This study aims to evaluate bibliometric parameters and citations of the literature of AVMs to provide an overview of how the field has evolved. We performed an electronic search on Web of Science to identify the top 100 published and indexed articles with the highest number of citations discussing the pathogenesis of AVMs. This study yielded 1863 articles, of which the top 100 were selected based on the highest total citation count. These articles included 24% basic science, 46% clinical, and 30% review articles. The most-cited article was a clinical article from 2003, and the most recent was published in 2022. The median number of authors was 6, with the highest being 46 for a clinical article. The top 5 journals were identified, with the highest impact factor being 20.1. 13 countries were identified, with the US contributing the most articles (approximately 70%). Regarding genes of investigation, VEGF was one of the early genes investigated, while more interested in RAS/MAPK has been garnered since 2015. There is a growing interest in AVM genomics and pathogenesis research. While progress has been made in understanding clinical aspects and risk factors, the exact pathophysiological mechanisms and genetic basis of AVM formation remain incompletely understood. Further investigation of key genes in AVM pathogenesis can allow identification of potential therapeutic targets.
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