NME1 and DCC variants are associated with susceptibility and tumor characteristics in Mexican patients with colorectal cancer

Rosa María Márquez-González ¹, Anilú Margarita Saucedo-Sariñana ¹, César de Jesús Tovar-Jacome ¹

⁰División de Medicina Molecular, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social (IMSS), Colonia Independencia Guadalajara, Sierra Mojada # 800, Jalisco, CP, 44340, México.

Journal of the Egyptian National Cancer Institute +

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March 31, 2024

View abstract on PubMed

Summary

Genetic variants in NME1 (rs34214448) and DCC (rs2229080) are linked to increased colorectal cancer (CRC) risk. These findings highlight specific genetic markers associated with CRC development, particularly in older individuals and those with rectal tumors.

Area Of Science

Oncology
Genetics
Molecular Biology

Background

Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide.
Nucleoside diphosphate kinase 1 (NME1) and netrin 1 receptor (DCC) genes are implicated in cancer suppression.
Investigating specific gene variants may reveal susceptibility factors for CRC.

Purpose Of The Study

To examine the association between NME1 (rs34214448, rs2302254) and DCC (rs2229080, rs714) gene variants and CRC susceptibility.
To identify potential genetic biomarkers for colorectal cancer risk.

Main Methods

Genotyping of NME1 and DCC variants in 232 CRC patients and 232 healthy controls.
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for variant identification.
Statistical analysis involved odds ratios (OR) and Bonferroni-corrected p-values.

Main Results

NME1 rs34214448 G/T and T/T genotypes significantly increased CRC susceptibility (OR=2.68, P=0.001; OR=2.47, P=0.001).
These NME1 variants were associated with increased risk in individuals over 50, early TNM stages, and rectal tumors.
DCC rs2229080 G/C genotype also elevated CRC risk (OR=2.00, P=0.002) and correlated with age, sex, and advanced TNM stages.

Conclusions

The NME1 rs34214448 and DCC rs2229080 variants are significantly associated with colorectal cancer development.
These genetic variants may serve as predictive markers for CRC susceptibility, particularly in specific demographic and clinical subgroups.

Keywords:

DCC genetic variants NME1 genetic variants Colorectal cancer Susceptibility TNM stage Tumor location