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Alpha-emitter therapy for pediatric relapsed metastatic pancreatic neuroendocrine tumor

Andrew Wahba1, Ebrahim S Delpassand2, Rodolfo Nunez2

  • 1Department of Pediatrics - Section of Hematology/Oncology, Texas Children's Hospital/Baylor College of Medicine, Houston, Texas, USA.

Pediatric Blood & Cancer
|April 1, 2024
PubMed
Abstract

No abstract available in PubMed .

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Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
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