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Sympathetic Pathophysiology in Hypertension Origins: The Path to Renal Denervation
Murray D Esler1, John W Osborn2, Markus P Schlaich1,3
1Human Neurotransmitter Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia (M.D.E., M.P.S.).
Hypertension (Dallas, Tex. : 1979)
|April 1, 2024
Summary
The sympathetic nervous system plays a key role in high blood pressure (hypertension). Recent advancements have led to new treatments like renal denervation for managing hypertension.
Area of Science:
- Cardiology
- Neuroscience
- Hypertension Research
Background:
- The sympathetic nervous system's role in hypertension was recognized in the early 20th century.
- Adrenergic therapies were developed, but interest waned until the 1980s.
- Advances in measuring sympathetic nerve activity confirmed its importance in hypertension.
Purpose of the Study:
- To review the historical and current understanding of the sympathetic nervous system in hypertension.
- To discuss the development and implications of catheter-based renal denervation as a treatment.
Main Methods:
- Historical review of research on sympathetic nervous system and hypertension.
- Discussion of advancements in measuring sympathetic nerve firing and transmitter release.
- Overview of catheter-based renal denervation technology and its application.
Main Results:
- The sympathetic nervous system is crucial for initiating and maintaining elevated blood pressure in hypertension.
- Precise measurement techniques have re-established the neural basis of hypertension.
- Catheter-based renal denervation has emerged as a device-based treatment option.
Conclusions:
- The sympathetic nervous system is a validated target for hypertension management.
- Renal denervation represents a significant advancement in device-based hypertension therapy.
- Further research and clinical application of renal denervation are warranted.
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