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Facilitating Repeat Intracarotid Injections in Mouse Models by a Novel Injection Site Repair Technique.

Daniel Ledbetter1, Joy Gumin1, Lynette Phillips1

  • 1Department of Neurosurgery, The University of Texas MD Anderson Cancer Center.

Journal of Visualized Experiments : Jove
|April 1, 2024
PubMed
Summary

A new method for intracarotid injections in mice allows for repeated therapeutic delivery to brain tumors. Repairing the common carotid artery after injection enables subsequent procedures without affecting treatment distribution.

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Area of Science:

  • Neuro-oncology
  • Vascular surgery
  • Preclinical research

Background:

  • Advances in endovascular delivery of antitumor therapeutics for neuro-oncology necessitate improved mouse models.
  • Intracarotid injections are crucial for delivering therapeutics to brain tumors in preclinical models.
  • Current methods often limit injections or cause complications like cerebral ischemia.

Purpose of the Study:

  • To develop and validate a reproducible method for intracarotid injections in mice.
  • To establish a technique for repairing the common carotid artery after injection to enable repeat procedures.
  • To assess the impact of injection site repair on therapeutic delivery and distribution.

Main Methods:

  • Developed a novel intracarotid injection technique in a mouse model.
  • Included two procedures: CCA ligation or CCA injection site repair.
  • Compared delivery of bone marrow-derived human mesenchymal stem cells (BM-hMSCs) with and without repair.

Main Results:

  • Injection site repair of the common carotid artery allows for subsequent injections.
  • Repairing the artery restores blood flow and avoids cerebral ischemia.
  • Delivery and distribution of BM-hMSCs were not significantly affected by the repair method.

Conclusions:

  • Injection site repair of the common carotid artery provides a flexible mouse model for repeated intracarotid injections.
  • This technique more closely mimics human intracarotid delivery procedures.
  • Enables advanced preclinical studies for neuro-oncology therapeutics.