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Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

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Related Experiment Video

Updated: Jun 29, 2025

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

DNA methylation in necrotizing enterocolitis.

Lauren C Frazer¹, Yukihiro Yamaguchi¹, Dhirendra K Singh¹

¹Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Expert Reviews in Molecular Medicine

|April 1, 2024

Summary

This summary is machine-generated.

DNA methylation patterns are altered in neonates with necrotizing enterocolitis (NEC), a severe intestinal disease. Further research may identify these epigenetic changes as biomarkers for early detection and targeted therapies.

Keywords:

DNA methylation epigenetics intestinal inflammation necrotizing enterocolitis neonatal prematurity

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Last Updated: Jun 29, 2025

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Published on: June 8, 2022

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A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis

Published on: November 30, 2021

Area of Science:

Epigenetics
Neonatal Health
Molecular Biology

Background:

Epigenetic modifications, including DNA methylation, regulate gene expression and are crucial for early development and inflammatory responses.
While research on epigenetics in neonatal health is emerging, specific roles in diseases of prematurity, like necrotizing enterocolitis (NEC), are under investigation.
Necrotizing enterocolitis (NEC) is a severe intestinal inflammatory disease in neonates, with its preceding factors and effective biomarkers yet to be fully determined.

Purpose of the Study:

To review the role of DNA methylation in neonatal health, focusing on its association with necrotizing enterocolitis (NEC).
To discuss recent findings on DNA methylation patterns in NEC patients and explore their potential as biomarkers.
To provide an overview of DNA methylation and its implications in disease states.

Main Methods:

Review of recent scientific literature on DNA methylation and necrotizing enterocolitis (NEC).
Analysis of studies reporting altered DNA methylation patterns in the stool and intestinal tissue of neonates with NEC.
Exploration of DNA methylation's utility as a biomarker in other disease contexts.

Main Results:

Altered DNA methylation patterns have been identified in the stool and intestinal tissue of neonates diagnosed with NEC.
These findings suggest a potential link between epigenetic dysregulation and the development of NEC.
Current literature highlights the need for further investigation into these methylation patterns.

Conclusions:

Altered DNA methylation patterns represent a promising area for NEC research.
Further studies are warranted to validate DNA methylation as a potential biomarker for NEC.
Identifying specific methylation patterns could lead to the development of targeted therapies and improved diagnostic tools for NEC.