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Obesity-related indicators and tuberculosis: A Mendelian randomization study
Nuannuan Cai1, Weiyan Luo1, Lili Ding1
1Pulmonary and Critical Care Medicine, Hainan Provincial People's Hospital, Haikou, Hainan, China.
Plos One
|April 1, 2024
Summary
Increased waist circumference is causally linked to tuberculosis (TB). This study used Mendelian randomization to investigate the obesity-TB relationship, identifying waist circumference as a potential risk factor for TB development.
Area of Science:
- Genetics
- Epidemiology
- Public Health
Background:
- Obesity is a significant risk factor for numerous diseases.
- The relationship between obesity and tuberculosis (TB) remains controversial due to conflicting research findings.
- A larger sample size is needed to clarify the obesity-TB association and guide treatment strategies.
Purpose of the Study:
- To determine the causal relationship between obesity indicators and tuberculosis.
- To investigate the potential role of waist circumference as a risk factor for TB.
- To inform potential treatment and prevention strategies for TB in obese individuals.
Main Methods:
- Utilized a two-sample Mendelian randomization (MR) analysis.
- Obesity indicators and TB mutation data were sourced from a genome-wide association study database.
- Instrumental variables (IVs) were screened, merged, and tested for stability and representativeness using sensitivity analysis.
Main Results:
- Two-sample MR analysis identified a causal relationship between increased waist circumference and TB.
- The analysis revealed an odds ratio of 2.13 (95% CI: 1.19-3.80, p=0.011) for TB associated with waist circumference.
- Sensitivity analyses confirmed the robustness and reliability of the instrumental variables, showing no heterogeneity or horizontal pleiotropy.
Conclusions:
- The study established a causal effect between waist circumference and tuberculosis.
- Both increased waist circumference and tuberculosis are identified as potential risk factors.
- Findings support the consideration of obesity management in TB prevention and treatment.
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