Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Laminar Flow01:27

Laminar Flow

1.0K
Laminar flow represents a smooth, orderly fluid motion where particles move along parallel paths, resulting in minimal mixing between layers. Streamlined particle paths characterize this flow regime and occur under conditions where viscous forces dominate over inertial forces. The distinction between laminar, transitional, and turbulent flow is primarily determined by the Reynolds number, a dimensionless quantity calculated as:
1.0K
Uniform Depth Channel Flow01:27

Uniform Depth Channel Flow

73
Uniform depth channel flow keeps fluid depth consistent along channels such as irrigation canals. In natural channels, such as rivers, approximate uniform flow is often assumed. This condition occurs when the channel’s bottom slope matches the energy slope, balancing potential energy lost from gravity with head loss due to shear stress. This balance prevents depth changes along the channel length, resulting in a steady, uniform flow.Uniform flow in open channels with a constant cross-section...
73
Poiseuille's Law and Reynolds Number01:10

Poiseuille's Law and Reynolds Number

6.6K
Any fluid in a horizontal tube can flow due to pressure differences—fluid flows from high to low pressure. The flow rate (Q) is the ratio of pressure difference and resistance through a horizontal tube. The greater the pressure difference, the higher the flow rate. The flow resistance is expressed as:
6.6K
General Characteristics of Pipe Flow II01:24

General Characteristics of Pipe Flow II

1.1K
When fluid enters a pipe, it first passes through the entrance region, where the velocity profile adjusts due to viscous effects. In this region, a boundary layer forms along the pipe walls and grows until it fully occupies the pipe's cross-section. Once the boundary layer merges, the flow becomes fully developed, with a steady velocity profile that remains consistent along the pipe's length.
The distance to reach a fully developed flow is called the entrance length and depends on the...
1.1K
Uniform Depth Channel Flow: Problem Solving01:18

Uniform Depth Channel Flow: Problem Solving

63
To calculate the flow rate for a trapezoidal channel, first, identify the bottom width, side slope, and flow depth of the channel. The cross-sectional area (A) corresponding to the depth of flow (y), channel bottom width (B), and side slope (θ) is determined by:Next, calculate the wetted perimeter, which includes the bottom width and the sloped side lengths in contact with the water. Using the values of the cross-sectional area and the wetted perimeter, determine the hydraulic radius by...
63
Steady, Laminar Flow in Circular Tubes01:23

Steady, Laminar Flow in Circular Tubes

199
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is...
199

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Control of lymphatic pacemaking and pumping by mechanobiological signals.

The Journal of physiology·2025
Same author

Modelling pacemaker oscillations in lymphatic muscle cells: lengthened action potentials by two distinct system effects.

Royal Society open science·2025
Same author

Fluid-Dynamic Modeling of Flow in Embryonic Tissue Indicates That Lymphatic Valve Location Is Not Consistently Determined by the Local Fluid Shear or Its Gradient.

Microcirculation (New York, N.Y. : 1994)·2024
Same author

IP3R1 underlies diastolic ANO1 activation and pressure-dependent chronotropy in lymphatic collecting vessels.

The Journal of general physiology·2023
Same author

A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R.

The Journal of general physiology·2023
Same journal

Computational Determination of Effective Working Length in Experimental Torsion Testing of Long Bones.

Journal of biomechanical engineering·2026
Same journal

Hierarchical Experimental Characterization of the Human Rib Cage for Nonlethal Projectile Impact Applications.

Journal of biomechanical engineering·2026
Same journal

An in vitro Experimental Model for Investigating Aortic Pressure Dynamics Under Blunt Thoracic Impacts.

Journal of biomechanical engineering·2026
Same journal

Editorial.

Journal of biomechanical engineering·2026
Same journal

Student Paper Competition of the 2025 ASME SB3C Summer Bioengineering Conference.

Journal of biomechanical engineering·2026
Same journal

Biomechanical Principles of Temporal Muscle Activation in Functional Movements: Implications for Stability and Movement Coordination.

Journal of biomechanical engineering·2026
See all related articles

Related Experiment Video

Updated: Jun 29, 2025

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.4K

The Lymphatic Vascular System: Does Nonuniform Lymphangion Length Limit Flow-Rate?

C D Bertram1

  • 1School of Mathematics and Statistics, University of Sydney, Sydney, New South Wales 2006, Australia.

Journal of Biomechanical Engineering
|April 1, 2024
PubMed
Summary
This summary is machine-generated.

Lymphatic vessel pumping is not disadvantaged by unequal lymphangion lengths. A computational model showed that variations in lymphangion length do not reduce lymphatic pumping efficiency.

More Related Videos

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
08:46

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research

Published on: March 22, 2024

1.2K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.4K

Related Experiment Videos

Last Updated: Jun 29, 2025

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.4K
Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research
08:46

Author Spotlight: Innovative Methods in Lymphedema and Hypertension Research

Published on: March 22, 2024

1.2K
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.4K

Area of Science:

  • Physiology
  • Biophysics
  • Computational Biology

Background:

  • Lymphatic vessels function as pumps, driven by contractions of sequential segments called lymphangions.
  • Lymphangion length can vary significantly in collecting lymphatic vessels, but the functional impact of this variation is not well understood.

Purpose of the Study:

  • To investigate whether lymphangions of unequal length reduce lymphatic pumping compared to lymphangions of equal length within a computational model.
  • To determine the impact of lymphangion length variation on overall lymphatic vessel pumping efficiency.

Main Methods:

  • A previously developed computational model of a lymphatic vessel as a chain of eight lymphangions was utilized.
  • The model incorporated passive elastic and active contractile properties, experimentally derived intravascular lymphatic valve dynamics, and autonomous pacemakers with signal transmission for contraction coordination.
  • Simulations were performed to compare pumping efficiency in chains with uniformly long lymphangions versus chains with unequal lymphangion lengths, controlling for overall chain length.

Main Results:

  • The model confirmed an expected flow-rate advantage conferred by longer lymphangions.
  • Contrary to anticipation, chains of unequal lymphangion lengths did not show a reduced pumping advantage compared to uniform chains of equal overall length.
  • Adverse pressure difference emerged as a more significant determinant of pumping dynamics than the arrangement of lymphangion lengths.

Conclusions:

  • The observed wide variation in lymphangion length within collecting lymphatic vessels does not appear to confer a disadvantage in terms of lymph pumping.
  • Lymphatic pumping efficiency is influenced more by pressure dynamics than by the uniformity of lymphangion segment lengths.