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Updated: Jun 29, 2025

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
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Retraction: "MiR-137 functions as a tumor suppressor in pancreatic cancer by targeting MRGBP"

    Journal of Cellular Biochemistry
    |April 1, 2024
    PubMed

    Insights

    This study on pancreatic cancer is retracted due to errors in figure compilation and unverifiable experimental data. The journal editors invalidated the article's conclusions regarding microRNA-137's tumor-suppressing role.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Biochemistry

    Context:

    • Pancreatic cancer is a highly lethal malignancy.
    • MicroRNAs (miRNAs) are implicated in cancer development.
    • The role of miR-137 in pancreatic cancer was previously investigated.

    Purpose:

    • To investigate the function of microRNA-137 (miR-137) as a tumor suppressor in pancreatic cancer.
    • To identify the target gene of miR-137, which was proposed to be MRGBP.

    Summary:

    • The article "MiR-137 functions as a tumor suppressor in pancreatic cancer by targeting MRGBP" has been retracted.
    • Retraction was based on author-acknowledged errors in figure compilation.
    • Inconsistencies in image elements and inability to verify experimental data led to the retraction.

    Impact:

    • The conclusions drawn in the original publication are considered invalid.
    • This retraction highlights the importance of data integrity and rigorous verification in scientific publishing.
    • Researchers should be aware of this retraction when consulting literature on miR-137 and pancreatic cancer.

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