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Updated: Aug 10, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Percutaneous Intramedullary Application of Stem Cells for Fifth Metatarsal Fractures Treated With a Cannulated Screw
Nikolaos E Koukoulias1, Evangelia Germanou2, Dimitris Koukoulias3
1Department of Sports Trauma and Orthopaedics, St. Luke's Hospital, Thessaloniki, GRC.
Abstract:
Non-union and refracture of fifth metatarsal fractures are common and devastating complications in the athletic population. Stem cell application at the fracture site, for biologic enhancement, is utilized to address this challenge. We present a simple technique to approach both the endosteum and the periosteum percutaneously, under a local anesthetic, in cases of cannulated screw intramedullary fixation.
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Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...