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Updated: May 6, 2026

Purification of Transcripts and Metabolites from Drosophila Heads
Published on: March 15, 2013
Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models
Ye-Jin Park1,2,3,4, Tzu-Chiao Lu1,2, Tyler Jackson1,2,5
1Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
None:
Peripheral tissues become disrupted in Alzheimer's Disease (AD). However, a comprehensive understanding of how the expression of AD-associated toxic proteins, Aβ42 and Tau, in neurons impacts the periphery is lacking. Using Drosophila, a prime model organism for studying aging and neurodegeneration, we generated the Alzheimer's Disease Fly Cell Atlas (AD-FCA): whole-organism single-nucleus transcriptomes of 219 cell types from adult flies neuronally expressing human Aβ42 or Tau. In-depth analyses and functional data reveal impacts on peripheral sensory neurons by Aβ42 and on various non-neuronal peripheral tissues by Tau, including the gut, fat body, and reproductive system. This novel AD atlas provides valuable insights into potential biomarkers and the intricate interplay between the nervous system and peripheral tissues in response to AD-associated proteins.
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