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Low-Dose Naltrexone for Excoriation Disorder.

Kevin Varghese¹, Xiaofeng Yan², Fei Cao³

¹School of Medicine, University of Missouri Kansas City, Kansas City, USA.

|April 1, 2024

Summary

This summary is machine-generated.

Low-dose naltrexone (LDN) at 4.5 mg may effectively manage Excoriation Disorder (skin-picking). This case report shows LDN improved symptoms and lesion healing, offering a potential new treatment avenue.

Keywords:

dermatology excoriation disorder naltrexone pain management skin-picking

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Area of Science:

Psychiatry
Pharmacology
Dermatology

Background:

Excoriation Disorder (ED) involves compulsive skin picking, causing distress and physical trauma.
Existing treatments for ED are varied, with naltrexone previously studied at higher doses (50 mg).
The efficacy of low-dose naltrexone (LDN) for ED has not been previously reported.

Observation:

A 51-year-old female with ED, also treated for fibromyalgia, was prescribed LDN (4.5 mg) for pain management.
The patient reported significant improvement in skin-picking compulsions and lesion healing after starting LDN.
Discontinuation of LDN led to a worsening of skin lesions, with improvement upon resumption.

Findings:

This case suggests LDN (4.5 mg) may be therapeutically beneficial for Excoriation Disorder.
Observed symptom improvement and lesion healing correlated with LDN use, and worsening occurred upon discontinuation.
This represents the first reported instance of ED improvement with LDN.

Implications:

LDN may offer a novel, lower-dose treatment option for Excoriation Disorder.
Further clinical trials are warranted to explore the efficacy and safety of LDN for ED.
This case supports considering LDN as a potential therapeutic trial for patients with ED.