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Primary central nervous system lymphoma.

Y Kawakami, K Tabuchi, R Ohnishi

    Journal of Neurosurgery
    |April 1, 1985
    PubMed
    Summary
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    This study analyzed 21 primary central nervous system (CNS) lymphoma cases. Chemotherapy, combined with surgery and irradiation, shows promise for treating this rare brain tumor.

    Area of Science:

    • Neurology
    • Oncology
    • Radiology

    Background:

    • Primary central nervous system (CNS) lymphoma is a rare malignancy.
    • Diagnosis often relies on characteristic neuroradiological findings.

    Purpose of the Study:

    • To analyze the clinical, radiological, and pathological features of primary CNS lymphoma.
    • To evaluate treatment outcomes for primary CNS lymphoma.

    Main Methods:

    • Retrospective analysis of 21 patients with primary CNS lymphoma.
    • Neuroradiological studies included brain scanning, cerebral arteriography, and computerized tomography (CT).
    • Histological and immunoglobulin studies were performed.

    Main Results:

    • Solitary supratentorial mass was the common presentation.

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  • Characteristic findings included increased uptake on brain scans, mass effect on arteriograms, and contrast enhancement on CT.
  • Histology revealed diffuse lymphoma, with B cell origin suggested by monoclonal spikes.
  • Chemotherapy, in addition to subtotal resection and whole-brain irradiation, appeared beneficial.

    • Conclusions:

    • Chemotherapy is a valuable addition to standard treatment for primary CNS lymphoma.
    • Multimodality treatment may improve outcomes for patients with this condition.