Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

828
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
828
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

206
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
206
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

133
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
133
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

209
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
209

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Review on Herbal Drugs and Natural Product Nano Formulations for Cancer Treatment.

Critical reviews in biomedical engineering·2025
Same author

Optimizing paracetamol-ascorbic acid effervescent tablet characteristics: a quality by design approach  .

Drug development and industrial pharmacy·2025
Same author

Unveiling the Rarity: A Case Report on Solitary Fibrous Tumor of the Thyroid Gland.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2024
Same author

Comparison of Two Grafted Copolymers, Soluplus and Kollicoat IR, as Solid Dispersion Carriers of Arteether for Oral Delivery Prepared by Different Solvent-Based Methods.

ACS omega·2023
Same author

Role of angiotensin receptor blockers in the context of Alzheimer's disease.

Fundamental & clinical pharmacology·2023
Same author

Thermoreversible Carbamazepine In Situ Gel for Intranasal Delivery: Development and In Vitro, Ex Vivo Evaluation.

AAPS PharmSciTech·2022

Related Experiment Video

Updated: Jun 29, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.1K

Lactoferrin Reduces Surfactant Content in the Self-Emulsifying Drug Delivery System.

Harish Khairnar1, Sanya Jain1, Bappaditya Chatterjee2

  • 1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, Mumbai 400056, India.

ACS Omega
|April 1, 2024
PubMed
Summary

Lactoferrin, a natural emulsifier, successfully reduced synthetic surfactant content in fenofibrate self-emulsifying drug delivery systems (SEDDS). This lactoferrin-containing SEDDS formulation significantly enhanced oral bioavailability in rats.

More Related Videos

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.0K
Enhanced Oil Recovery using a Combination of Biosurfactants
13:19

Enhanced Oil Recovery using a Combination of Biosurfactants

Published on: June 3, 2022

5.2K

Related Experiment Videos

Last Updated: Jun 29, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.1K
Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes
09:51

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

Published on: March 3, 2020

9.0K
Enhanced Oil Recovery using a Combination of Biosurfactants
13:19

Enhanced Oil Recovery using a Combination of Biosurfactants

Published on: June 3, 2022

5.2K

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Biomaterials

Background:

  • Self-emulsifying drug delivery systems (SEDDSs) improve oral bioavailability for poorly soluble drugs.
  • High synthetic surfactant content poses challenges for SEDDS formulation.
  • Lactoferrin offers potential as a natural emulsifier to reduce synthetic surfactant load.

Purpose of the Study:

  • To develop a fenofibrate SEDDS using lactoferrin to decrease synthetic surfactant content.
  • To evaluate the physicochemical properties and in vitro drug release of the lactoferrin-modified SEDDS.
  • To assess the in vivo oral pharmacokinetic performance of the novel SEDDS formulation.

Main Methods:

  • Formulation of fenofibrate SEDDS with and without lactoferrin, varying Tween content.
  • Thermodynamic stability, zeta potential, drug content, and transmittance analysis.
  • In vitro drug release studies of solidified SEDDS and pharmacokinetic evaluation in rats.

Main Results:

  • Lactoferrin-containing SEDDS (FEN Lf-SEDDS) showed reduced Tween content (21%) compared to conventional SEDDS (30%).
  • Both formulations exhibited thermodynamic stability, similar zeta potential, drug content, and transmittance.
  • FEN Lf-SEDDS demonstrated significantly improved oral bioavailability (1.3-5.5 times higher) in a rat model.

Conclusions:

  • Lactoferrin can effectively substitute synthetic surfactants in SEDDS, reducing Tween content by 27% while maintaining similar physicochemical properties.
  • The developed lactoferrin-modified SEDDS offers enhanced oral bioavailability for fenofibrate.
  • This approach presents a promising strategy for developing safer and more effective oral drug delivery systems.