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Severe Elevated Bile Acids in Early Pregnancy
Lucas Fass1, Carrie Sibbald2, Erin Bailey2
1Department of Internal Medicine, University of Wisconsin Hospital and Clinics, Madison, WI.
Early pregnancy elevated bile acids in a patient with liver disease may differ from intrahepatic cholestasis of pregnancy (ICP). Therapeutic plasma exchange with enoxaparin was a safe and effective treatment option.
Area of Science:
- Hepatology
- Obstetrics
- Cardiology
Background:
- Intrahepatic cholestasis of pregnancy (ICP) usually occurs in the second half of pregnancy and carries a risk of stillbirth.
- Elevated bile acids in the first trimester are not well understood, especially in patients with pre-existing conditions.
- The case involves a patient with pre-existing cholestatic liver disease and aortic valve disease requiring anticoagulation.
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