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Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
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Severe Elevated Bile Acids in Early Pregnancy

Lucas Fass1, Carrie Sibbald2, Erin Bailey2

  • 1Department of Internal Medicine, University of Wisconsin Hospital and Clinics, Madison, WI.

ACG Case Reports Journal
|April 1, 2024
PubMed

Intrahepatic cholestasis of pregnancy (ICP) typically presents in the second half of pregnancy. Severe ICP is associated with increased risk of stillbirth. Little is known regarding elevated bile acids in the first trimester. We present a case of severely elevated bile acids in the first trimester, resistant to conservative management, in a patient with pre-existing cholestatic liver disease and aortic valve disease requiring anticoagulation. Therapeutic plasma exchange was used. In those with pre-existing cholestatic disease, early bile acid elevation is likely distinct from ICP, and conservative strategies may not be useful. In addition, therapeutic enoxaparin appears safe in therapeutic plasma exchange.

Keywords:
Bile acidsPregnancyductopeniantrahepatic cholestasis of pregnancyvanishing bile duct syndrome

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