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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
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Gastric Mucormycosis: An Infection of Fungal Invasion into the Gastric Mucosa in Immunocompromised Patients.

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Systemic Amyloid A Protein Amyloidosis With Gastrointestinal Involvement.

Olubunmi Akharume1, Solabomi Ojeniyi1, Haider A Naqvi1

  • 1Department of Medicine, Medstar Union Memorial Hospital and Medstar Franklin Square Medical Center, Baltimore, MD.

ACG Case Reports Journal
|April 1, 2024
PubMed
Summary

Systemic amyloid A protein amyloidosis is a kidney complication in people who inject drugs. This case highlights rare gastrointestinal bleeding as a symptom of this condition.

Keywords:
GI amyloidosisPWIDbiopsyrenal AA amyloidosisskin and soft tissue infection

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Area of Science:

  • Nephrology
  • Gastroenterology
  • Infectious Disease

Background:

  • Systemic amyloid A protein (AA) amyloidosis predominantly affects the kidneys and is often under-recognized in individuals who inject drugs.
  • Gastrointestinal involvement is uncommon in systemic AA amyloidosis, particularly when associated with illicit drug use.

Observation:

  • A 40-year-old male with a history of injection drug use, recurrent skin infections, and renal AA amyloidosis presented with painless bloody bowel movements.
  • The patient also developed empyema requiring medical intervention and experienced recurrent hematochezia during hospitalization.

Findings:

  • Gastrointestinal biopsy confirmed amyloid deposits as the cause of the patient's symptoms.
  • This case illustrates an unusual presentation of systemic AA amyloidosis.

Implications:

  • Highlights the importance of considering systemic AA amyloidosis in individuals with a history of drug use presenting with unexplained gastrointestinal bleeding.
  • Emphasizes the need for increased awareness of gastrointestinal manifestations of AA amyloidosis in this patient population.
  • Suggests potential for earlier diagnosis and management of AA amyloidosis complications.