Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants

Drugs Acting on Autonomic Ganglia: Stimulants

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Nomograms Predictive of Recurrence in Malignant Tumors Treated With Skull Base Surgery: An International Collaborative Study.

Head & neck·2026

Same author

Olfactory Dysfunction and Metabolic Syndrome Components: A Systematic Review and Meta-Analysis.

The Laryngoscope·2026

Same author

Clinical Characteristics, Diagnostic Features, and Medical Treatment of Sinonasal Sarcoidosis: A Systematic Review.

American journal of rhinology & allergy·2026

Same author

Small Business Grants Awarded by the National Institutes of Health for Rhinologic Diseases, 1985-2024.

International forum of allergy & rhinology·2026

Same author

Determining the Minimal Clinically Important Difference of the 40-Item Smell Identification Test in People With Cystic Fibrosis.

International forum of allergy & rhinology·2026

Same author

Medicaid Coverage and Utilization for Novel Therapies for Chronic Rhinosinusitis With Nasal Polyposis.

International forum of allergy & rhinology·2026

Search research articles

Related Experiment Video

Updated: Jun 29, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

Comparison of trigeminal lateralization with differing stimulants.

Tiffany Chen¹, Nicolas S Poupore¹, Michael C Shih¹

¹Department of Otolaryngology-Head and Neck Surgery Medical University of South Carolina Charleston South Carolina USA.

World Journal of Otorhinolaryngology - Head and Neck Surgery

|April 1, 2024

Summary

Trigeminal sensitivity varies across different transient receptor potential (TRP) receptors, as stimulant responses did not correlate. This suggests TRP receptor dysfunction may cause distinct patient symptoms, requiring further research.

Keywords:

TRP receptor chemosensory olfaction trigeminal

More Related Videos

Transcranial Direct Current Stimulation tDCS of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition

Transcranial Direct Current Stimulation tDCS of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition

Published on: July 13, 2019

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

Related Experiment Videos

Last Updated: Jun 29, 2025

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation

Published on: November 26, 2019

Transcranial Direct Current Stimulation tDCS of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition

Transcranial Direct Current Stimulation tDCS of Wernicke's and Broca's Areas in Studies of Language Learning and Word Acquisition

Published on: July 13, 2019

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Two Different Real-Time Place Preference Paradigms Using Optogenetics within the Ventral Tegmental Area of the Mouse

Published on: February 12, 2020

Area of Science:

Neuroscience
Sensory Science
Ophthalmology

Background:

Trigeminal nerve stimulants activate specific receptors, influencing sensory perception.
Variability in trigeminal sensitivity across different transient receptor potential (TRP) receptors is not well understood.
Dysfunction of TRP receptors may lead to diverse patient symptoms.

Purpose of the Study:

To investigate trigeminal sensitivity across different TRP receptors.
To determine if trigeminal sensitivity is consistent across various stimulants.
To explore correlations between trigeminal sensitivity, olfaction, and patient-reported outcomes.

Main Methods:

Prospective cohort study with 50 participants across the olfactory spectrum.
Trigeminal lateralization testing using eucalyptol, isothiocyanate (mustard oil), and acetic acid (vinegar).
Olfaction testing with Sniffin' Sticks and measurement of patient-reported outcome measures (PROMs).

Main Results:

Mean trigeminal lateralization scores: eucalyptol (16.18), mustard oil (14.94), vinegar (15.28).
Eucalyptol correlated with olfactory threshold scores; acetic acid correlated with PROMs.
No significant correlation found between lateralization scores of different stimulants or with age.

Conclusions:

Trigeminal sensitivity is receptor-specific, with no cross-correlation observed between tested stimulants.
Findings suggest that sensitivity to one TRP receptor type may not predict sensitivity to others.
Further research with TRPV1 and TRPA1 agonists is recommended to validate these findings.