Post-PCI corrected TIMI Frame Count predicts left ventricular global longitudinal strain at 90 days post-STEMI in
Ioannis Anastasiou1, Alexandros Patrianakos1, Michail Vernardos1
1University Hospital of Heraklion, Cardiology Department, Heraklion, Crete, Greece.
Summary
Ticagrelor and clopidogrel showed similar myocardial recovery in ST-segment elevation myocardial infarction (STEMI) patients treated with thrombolysis. Post-PCI microvascular integrity predicts 3-month left ventricular function.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Ticagrelor is a preferred P2Y12-inhibitor for STEMI patients undergoing primary PCI.
- Its efficacy in thrombolysis-treated patients requires further investigation.
Purpose of the Study:
- To compare left ventricular systolic function recovery at 90 days between ticagrelor and clopidogrel in STEMI patients treated with thrombolysis.
- To assess corrected TIMI Frame Count (CTFC) as a predictor of myocardial recovery.
Main Methods:
- Pre-specified analysis of the MIRTOS trial.
- Compared changes in left ventricular ejection fraction (ΔLVEF) and longitudinal strain (ΔLV-GLS) using echocardiography.
- Evaluated correlations between speckle-tracking measurements and post-PCI CTFC.
Main Results:
- No significant differences in ΔLVEF or ΔLV-GLS between ticagrelor and clopidogrel groups.
- A strong negative correlation was observed between post-PCI CTFC and LV-GLS at 90 days.
Conclusions:
- Both P2Y12-inhibitors facilitate similar myocardial recovery in thrombolysis-treated STEMI patients.
- Post-PCI microvascular integrity (CTFC) predicts 3-month left ventricular systolic function.
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