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Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

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Updated: Jun 29, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

CXCL5 gene polymorphisms and coronary collateralization.

Ellen C Keeley^1,2, Michael R Blotner¹, Lewis C Lipson³

¹Department of Medicine, University of Florida, Gainesville, FL, United States of America.

American Heart Journal Plus : Cardiology Research and Practice

|April 1, 2024

Summary

This summary is machine-generated.

Genetic variations in CXCL5 may influence coronary collateralization. This study found that carrying a CXCL5 polymorphism was a negative predictor of visible coronary collaterals, suggesting a genetic component to this important cardiovascular adaptation.

Keywords:

CXCL5 single nucleotide polymorphism Coronary collaterals

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Area of Science:

Cardiovascular Genetics
Angiogenesis Research
Coronary Artery Disease

Background:

Coronary collateralization varies significantly among patients with similar coronary artery stenoses.
The chemokine CXCL5 is known to mediate angiogenesis, the formation of new blood vessels.

Purpose of the Study:

To investigate the association between genetic variations in CXCL5 and the presence of coronary collateralization.
To explore the potential role of genetic factors in determining coronary collateral development.

Main Methods:

Genotyping of single nucleotide polymorphisms (SNPs) in the CXCL5 gene in patients undergoing coronary angiography.
Assessment of spontaneously visible coronary collaterals using angiographic criteria.

Main Results:

Patients with coronary collaterals exhibited less angina and prior percutaneous coronary intervention but more hyperlipidemia, peripheral arterial disease, congestive heart failure, and multi-vessel coronary artery disease.
Multi-vessel disease and hyperlipidemia were identified as positive predictors of visible collaterals.
Carrying a CXCL5 polymorphism was found to be a negative predictor of angiographically visible coronary collaterals.

Conclusions:

Coronary collateralization appears to be, at least partially, influenced by genetic factors.
CXCL5 genetic variation may play a role in modulating the development of coronary collateral circulation.