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Updated: Jun 29, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
CXCL5 gene polymorphisms and coronary collateralization
Ellen C Keeley1,2, Michael R Blotner1, Lewis C Lipson3
1Department of Medicine, University of Florida, Gainesville, FL, United States of America.
Insights
Genetic variations in CXCL5 may influence coronary collateralization. This study found that carrying a CXCL5 polymorphism was a negative predictor of visible coronary collaterals, suggesting a genetic component to this important cardiovascular adaptation.
Area of Science:
- Cardiovascular Genetics
- Angiogenesis Research
- Coronary Artery Disease
Background:
- Coronary collateralization varies significantly among patients with similar coronary artery stenoses.
- The chemokine CXCL5 is known to mediate angiogenesis, the formation of new blood vessels.
Purpose of the Study:
- To investigate the association between genetic variations in CXCL5 and the presence of coronary collateralization.
- To explore the potential role of genetic factors in determining coronary collateral development.
Main Methods:
- Genotyping of single nucleotide polymorphisms (SNPs) in the CXCL5 gene in patients undergoing coronary angiography.
- Assessment of spontaneously visible coronary collaterals using angiographic criteria.
Main Results:
- Patients with coronary collaterals exhibited less angina and prior percutaneous coronary intervention but more hyperlipidemia, peripheral arterial disease, congestive heart failure, and multi-vessel coronary artery disease.
- Multi-vessel disease and hyperlipidemia were identified as positive predictors of visible collaterals.
- Carrying a CXCL5 polymorphism was found to be a negative predictor of angiographically visible coronary collaterals.
Conclusions:
- Coronary collateralization appears to be, at least partially, influenced by genetic factors.
- CXCL5 genetic variation may play a role in modulating the development of coronary collateral circulation.
Background:
The presence of coronary collateralization is heterogenous, even amongst those with similar degrees of epicardial coronary artery stenoses. We hypothesized that genetic variation of CXCL5, a chemokine that mediates angiogenesis, is associated with coronary collateralization.
Methods:
We genotyped subjects undergoing coronary angiography for single nucleotide polymorphisms of CXCL5 and determined the presence of spontaneously visible coronary collaterals.
Results:
Subjects with collaterals had less angina (46 % vs 59 %, p = 0.006), and prior percutaneous coronary intervention (34 % vs 47 %, p = 0.010), and more hyperlipidemia (90 % vs 82 %, p = 0.018), peripheral arterial disease (25 % vs 17 %, p = 0.041), congestive heart failure (16 % vs 8 %, p = 0.007), and multi-vessel coronary artery disease (41 % vs 24 %, p = 0.0001) compared to those without collaterals. Multi-vessel disease and hyperlipidemia were positive predictors of angiographically visible collaterals while being a carrier of the CXCL5 polymorphism was a negative predictor.
Conclusions:
Coronary collateralization may, at least in part, be genetically determined.
