Related Experiment Video

Updated: Aug 16, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

85.9K

Insulin-like growth factor-1 and insulin-like growth factor binding protein-3 as early predictors of growth, body

Megan E Paulsen1,2,3, Nicholas Marka4, Scott Lunos4

  • 1Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA. megan.paulsen@childrensmn.org.

Journal of Perinatology : Official Journal of the California Perinatal Association
|April 1, 2024
PubMed

Insights

Early insulin-like growth factor binding protein 3 (IGFBP-3) levels in preterm infants correlate with better neurodevelopment. Insulin-like growth factor 1 (IGF-1) is linked to improved growth outcomes.

Area of Science:

  • Neonatal Research
  • Endocrinology
  • Developmental Pediatrics

Background:

  • Preterm infants face risks for impaired growth, body composition, and neurodevelopment.
  • Insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are crucial for fetal and postnatal development.
  • Understanding their role in preterm infants is vital for optimizing long-term outcomes.

Purpose of the Study:

  • To examine the association between IGF-1, IGFBP-3 levels and growth, body composition, and neurodevelopment in preterm infants.
  • To identify potential early biomarkers for predicting long-term outcomes in this vulnerable population.

Main Methods:

  • Prospective cohort study of 50 infants born at or before 32 weeks gestational age.
  • Measurement of IGF-1 and IGFBP-3 at 1 week (early) and 35 weeks (late) post-menstrual age (PMA).
  • Assessment of growth, body composition, and neurodevelopment at 4 and 12 months PMA using linear regression analysis.

Main Results:

  • Early IGFBP-3 concentrations positively correlated with neurodevelopment at 12 months PMA.
  • Early IGF-1 concentrations were associated with increased weight at 4 months PMA, head circumference at 12 months PMA, and body mass index at 12 months PMA.
  • Late IGFBP-3 concentrations showed a positive association with weight at 4 months PMA.

Conclusions:

  • Early IGF-1 and IGFBP-3 levels may serve as predictive biomarkers for growth and neurodevelopmental outcomes in preterm infants.
  • These findings suggest potential targets for therapeutic interventions to improve health in preterm populations.
  • Further research is warranted to explore these associations for novel biomarker and treatment development.
Abstract

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

10.0K
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development05:44

Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development

Published on: May 17, 2024

561

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
Environmental Influences on Intelligence01:29

Environmental Influences on Intelligence

Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children from...