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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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  1. Home
  3. Unconventional Human Cd61 Pairing With Cd103 Promotes Tcr Signaling And Antigen-specific T Cell Cytotoxicity.
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  3. Unconventional Human Cd61 Pairing With Cd103 Promotes Tcr Signaling And Antigen-specific T Cell Cytotoxicity.

Related Experiment Video

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.

Megat H B A Hamid1, Pablo F Cespedes1,2, Chen Jin1,3

  • 1CAMS Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Nature Immunology
|April 1, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Researchers discovered CD61, a protein transiently expressed with CD103 on T cells, enhances anti-tumor immunity. This finding offers a new therapeutic target for improving cancer immunotherapy and patient outcomes.

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Related Experiment Videos

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Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue
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Assessment of the Synaptic Interface of Primary Human T Cells from Peripheral Blood and Lymphoid Tissue

Published on: July 30, 2018

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Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
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Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Cancer immunotherapy aims to harness the immune system to fight tumors.
  • CD103-expressing T cells are linked to favorable cancer prognoses, but their precise mechanisms are unknown.
  • Understanding T cell interactions is crucial for developing effective cancer treatments.

Purpose of the Study:

  • To elucidate the unclear immune mechanisms behind CD103-mediated protective immunity in cancer.
  • To investigate the role of CD61 expression in conjunction with CD103 on T cells.
  • To identify novel targets for cancer immunotherapy.

Main Methods:

  • Analysis of T cell synaptic microclusters.
  • Investigating CD61 and CD103 colocalization.
  • Assessing T cell receptor signaling modulation.
  • Evaluating antitumor cytotoxicity and tumor growth control.
  • Clinical correlation of CD61+ tumor-infiltrating lymphocytes with patient outcomes.

    • Main Results:

    • An unexpected, transient expression of CD61 was observed, paired with CD103 at T cell synaptic microclusters.
    • CD61 colocalization with the T cell receptor enhanced downstream signaling.
    • This interaction improved antitumor cytotoxicity and controlled tumor growth.
    • CD61+ tumor-infiltrating T lymphocytes correlated with better clinical outcomes, enhanced effector functions, and reduced cellular exhaustion.

    Conclusions:

    • A novel, unconventional pairing of transient CD61 and CD103 on human immune cells was identified.
    • This CD61/CD103 interaction potentiates T cell-mediated antitumor immunity.
    • The study presents a new potential target for immune-based cellular therapies in cancer treatment.