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NCI Resources for Cancer Immunoprevention Research
Shizuko Sei1, Sudhir Srivastava1, Halonna R Kelly2
1Division of Cancer Prevention, NCI, NIH, Bethesda, Maryland.
Cancer Immunology Research
|April 2, 2024
Summary
Harnessing the immune system for cancer immunoprevention offers a promising strategy for early intervention. Research focuses on developing interventions before or during early cancer development to reduce incidence and mortality.
Area of Science:
- Oncology
- Immunology
- Preventive Medicine
Background:
- National Cancer Plan emphasizes prevention and early detection.
- Advances in tumor immunology, immunotherapy, and vaccinology support cancer immunoprevention.
- Cancer immunoprevention is most effective when the immune system is uncompromised.
Purpose of the Study:
- To highlight the Division of Cancer Prevention's (DCP) focus on cancer immunoprevention research.
- To outline the resources and collaborations facilitating immunoprevention research.
- To detail the diverse research activities supported by DCP.
Main Methods:
- Biomarker discovery and validation for cancer risk assessment and early detection.
- Elucidation of precancer growth mechanisms and control.
- Multiomics characterization of precancerous lesions.
- Discovery of immunoprevention pathways and immune targets.
- Preclinical and clinical development of novel immunoprevention and interception agents.
Main Results:
- DCP has increased emphasis and resources for immunoprevention research.
- Interagency collaborations are expanding to facilitate research.
- A wide array of basic, translational, and clinical research activities are supported.
Conclusions:
- Cancer immunoprevention is a key strategy for reducing cancer incidence and mortality.
- DCP supports comprehensive research from basic discovery to clinical development.
- Continued investment in immunoprevention research is crucial for advancing cancer control.
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