Related Experiment Video
Updated: Jun 29, 2025
Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
Published on: June 20, 2019
Progress of the acyl-Coenzyme A thioester hydrolase family in cancer
Lu Bai1,2, Pengjie Yang3, Bater Han3
1Inner Mongolia Medical University, Hohhot, China.
Abstract:
In recent years, the acyl-Coenzyme A thioester hydrolase family (ACOTs) has received wide attention as a key link in lipid metabolism. This family is a class of enzymes that catalyze the hydrolysis of fatty acyl-Coenzyme A, disrupting the thioester bond present within acyl-CoA ester molecules to produce free fatty acids (FFA) and the corresponding coenzyme A (CoA). Such enzymes play a very important role in lipid metabolism through maintaining appropriate levels of intracellular FFA and fatty acyl-CoA as well as CoA. It is broadly divided into two distinct subgroups, the type-I α/β-hydrolase fold enzyme superfamily and the type-II 'hot dog' fold superfamily. There are currently four human type-I genes and eight human type-II genes. Although the two subgroups catalyze the same reaction, they are not structurally similar, do not share the same sequence homology, and differ greatly in protein executive functions. This review summarizes the classification of the acyl-CoA thioester hydrolase family, an overview of the structural sequences, and advances in digestive, respiratory, and urinary systemic tumors. In order to explore potential specific drug targets and effective interventions, to provide new strategies for tumor prevention and treatment.
Insights
The acyl-Coenzyme A thioester hydrolase (ACOTs) family regulates lipid metabolism by hydrolyzing fatty acyl-Coenzyme A. This review explores ACOTs
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- The acyl-Coenzyme A thioester hydrolase (ACOTs) family are key enzymes in lipid metabolism, hydrolyzing fatty acyl-Coenzyme A to regulate free fatty acids and Coenzyme A levels.
- ACOTs are divided into two structurally distinct superfamilies: type-I (α/β-hydrolase fold) and type-II ('hot dog' fold), with four and eight human genes, respectively.
- Despite catalyzing the same reaction, these subgroups differ significantly in structure, sequence homology, and protein functions.
Purpose of the Study:
- To review the classification and structural characteristics of the ACOTs family.
- To summarize recent advances concerning ACOTs in digestive, respiratory, and urinary systemic tumors.
- To identify potential drug targets and therapeutic strategies for tumor prevention and treatment.
Main Methods:
- Literature review of ACOTs family classification and structure.
- Analysis of ACOTs' role in various systemic tumors.
- Exploration of ACOTs as potential therapeutic targets.
Main Results:
- The review details the classification and structural diversity within the ACOTs family.
- Advances in understanding ACOTs' involvement in digestive, respiratory, and urinary system tumors are presented.
- The study highlights ACOTs' potential as specific drug targets for cancer intervention.
Conclusions:
- The ACOTs family plays a critical role in lipid metabolism and is implicated in various systemic tumors.
- Understanding ACOTs' structural and functional diversity is crucial for developing targeted cancer therapies.
- Further research into ACOTs may yield novel strategies for tumor prevention and treatment.
More Related Videos
10:26Assessment of Mitochondrial Health in Cancer-Associated Fibroblasts Isolated from 3D Multicellular Lung Tumor Spheroids
Published on: October 21, 2022
08:29SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Published on: November 1, 2019
Related Concept Videos
02:07Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:53Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
03:03mTOR Signaling and Cancer Progression
The mTOR pathway or the...
01:33Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:46Electron Transport Chain: Complex I and II
ROS generation is regulated and maintained at moderate levels necessary...