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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
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The relationship between autoimmune thyroid disease, thyroid nodules and sleep traits: a Mendelian randomization
Suijian Wang1, Kui Wang2, Xiaohong Chen1
1Department of Endocrinology, The First Affiliated Hospital, School of Medicine, Shantou University, Shantou, China.
Frontiers in Endocrinology
|April 2, 2024
Summary
Waking up earlier may protect against autoimmune hypothyroidism, but other sleep traits like duration or napping show no causal link to thyroid conditions. Further research is needed for thyroid nodules and Graves' disease.
Area of Science:
- Endocrinology
- Genetics
- Sleep Medicine
Background:
- Limited and controversial evidence suggests a link between autoimmune thyroid disease, thyroid nodules, and sleep traits.
- The precise causal relationship between these conditions remains unclear, necessitating further investigation.
Purpose of the Study:
- To investigate the potential causal relationships between autoimmune thyroid disease, thyroid nodules, and various sleep traits.
- To clarify the role of specific sleep behaviors in the development or progression of thyroid disorders.
Main Methods:
- Utilized Mendelian randomization (MR) analysis with summary statistics from genome-wide association studies (GWAS) in European ancestry.
- Employed multiple MR techniques (IVW, weighted median, MR-Egger, MR-PRESSO) to ensure robustness and assess heterogeneity and pleiotropy.
Main Results:
- A significant protective causal effect of 'Getting up' (earlier waking) was observed for autoimmune hypothyroidism (OR: 0.59, P = 1.99e-4).
- Potential correlations between sleep duration and autoimmune hypothyroidism, and daytime napping and thyroid nodules, were noted but require cautious interpretation due to potential pleiotropy.
- No significant causal relationships were found between other sleep traits and thyroid nodules or Graves' disease.
Conclusions:
- 'Getting up' (earlier waking) may act as a protective factor against autoimmune hypothyroidism.
- Current evidence does not support a causal link between the investigated sleep traits and thyroid nodules or Graves' disease.
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