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Quantitating SARS-CoV-2 Neutralizing Antibodies from Human Dried Blood Spots
Katherine Berman1, Greta Van Slyke1, Hayley Novak1
1Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208.
Dried blood spots (DBS) can reliably measure neutralizing antibodies against SARS-CoV-2. This method enables functional antibody assessment in diverse populations, including vulnerable and hard-to-reach communities.
Area of Science:
- Immunology
- Virology
- Public Health
Background:
- Dried blood spots (DBS) were crucial for early COVID-19 pandemic seroprevalence studies.
- With high SARS-CoV-2 seropositivity, focus shifts to assessing functional antibodies using DBS.
- Evaluating neutralizing antibodies in specific cohorts is now a key public health objective.
Conclusions:
- Dried blood spots (DBS) are suitable for reliably measuring SARS-CoV-2 neutralizing antibodies.
- This validates DBS as a valuable tool for functional antibody assessment in various populations.
- DBS facilitates the study of vulnerable and hard-to-reach communities, expanding public health surveillance capabilities.
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