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Synthesis of 2-(Pyridin-2-yl)phenols and 2-(Pyridin-2-yl)anilines
Keigo Miki1, Katsumi Maeda1, Ryosuke Matsubara1
1Department of Chemistry, Graduate School of Science, Kobe University, Nada, Kobe 657-8501, Japan.
Abstract:
Herein, we report a new synthetic strategy for 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines catalyzed by a Pd/C-ethylene system. The starting materials, 2-(pyridin-2-yl)cyclohexan-1-ones, can be easily prepared by the reaction of substituted pyridine N-oxide and cyclohexanones. The most useful feature of this method is that both 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines are easily synthesized independently using the same compound as a starting material, simply by adding or not adding a nitrogen source.
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