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Updated: Jun 29, 2025

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DLC1 promotes mechanotransductive feedback for YAP via RhoGAP-mediated focal adhesion turnover

Aukie Hooglugt1,2, Miesje M van der Stoel1, Apeksha Shapeti3

  • 1Amsterdam UMC, University of Amsterdam, Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, 1105AZ Amsterdam, the Netherlands.

Journal of Cell Science
|April 2, 2024
PubMed
Summary

The deleted-in-liver-cancer-1 (DLC1) protein negatively regulates YAP/TAZ activity by reducing their nuclear localization. This feedback loop is essential for controlling endothelial cell migration during sprouting angiogenesis.

Keywords:
AngiogenesisDLC1EndotheliumFocal adhesionForceIntegrinMechanotransductionMigrationRho GTPaseStiffnessYAP/TAZ

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