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Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...

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Related Experiment Video

Updated: Jul 9, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

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Published on: December 7, 2013

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Development and Implementation of an Integrated Preclinical Atherosclerosis Database.

Rachel R Xiang1, Yihua Wang1, Megan M Shuey2

  • 1Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA (R.R.X., Y.W., B.V.C., I.Z.J.).

Circulation. Genomic and Precision Medicine
|April 2, 2024
PubMed
Summary

Integrating preclinical data from mouse models of atherosclerosis can improve the translation of basic science discoveries to clinical care. This study created a database of atherosclerosis research to enable comprehensive analysis and accelerate disease research.

Keywords:
atherosclerosisdatabasemice, transgenicplaque, atherosclerotictranslational research, biomedical

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Related Experiment Videos

Last Updated: Jul 9, 2026

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Area of Science:

  • Cardiovascular Research
  • Translational Medicine
  • Bioinformatics

Background:

  • Preclinical animal models are crucial for understanding human disease mechanisms, yet translation to clinical practice remains limited.
  • Thousands of publications support causative inferences from animal studies, but a lack of integration hinders progress.
  • An integrated approach to preclinical data offers potential for improved translational success in medicine.

Purpose of the Study:

  • To develop a comprehensive database of preclinical atherosclerosis research using common mouse models.
  • To facilitate integrated analyses of experimental conditions, interventions, and outcomes from published studies.
  • To provide a resource for interrogating the global impact of atherosclerosis research and improving translational outcomes.

Main Methods:

  • Extracted data from mouse models of atherosclerosis (ApoE-knockout and LDLR-knockout) published in key journals.
  • Collected predefined variables including animal sex, diet, intervention, and plaque pathologies (size, inflammation, lipid content).
  • Developed procedures for data standardization, intervention attribution, and transformation for transcriptomics software.

Main Results:

  • Created a preclinical atherosclerosis database integrating hundreds of genes tested in vivo.
  • The database includes detailed information on experimental conditions and outcomes from published atherosclerosis research.
  • Standardized data extraction and transformation methods are provided for community use.

Conclusions:

  • The database serves as a resource for interrogating specific data subsets related to plaque pathologies, cell types, or sex.
  • Provided methods and software can expand the dataset and be applied to other human diseases studied in preclinical models.
  • This integrated approach aims to enhance the translation of preclinical findings into clinical advancements.